Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVR1 | Q04771 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23132329 | 0.85 | ACVR1 (0.38) | ACVR1ALDH1A1HSD17B10HTTSMN1; SMN2 | |
| SCHEMBL23089587 | 0.85 | ACVR1 (0.38) | ACVR1KDM4EHSD17B10NPSR1HTT | |
| SCHEMBL23090516 | 0.84 | GABRP (0.48) | ACVR1HTTSMN1; SMN2HPGDHSP90AA1 | |
| SCHEMBL23102918 | 0.82 | ACVR1 (0.38) | ACVR1HTTSMN1; SMN2HPGDHSP90AA1 | |
| SCHEMBL28876635 | 0.79 | ACVR1 (0.38) | ACVR1HTTSMN1; SMN2HPGDHSP90AA1 | |
| SCHEMBL29736514 | 0.79 | MAPKAPK2 (0.37) | ACVR1 | |
| SCHEMBL23104045 | 0.79 | MAPKAPK2 (0.37) | ACVR1 | |
| SCHEMBL30027960 | 0.75 | EGFR (0.54) | KDM4EALDH1A1HSD17B10NPSR1SMN1; SMN2 | |
| SCHEMBL11403516 | 0.69 | KDM4E (0.62) | ACVR1KDM4EALDH1A1HSD17B10SMN1; SMN2 | |
| SCHEMBL24992666 | 0.68 | KDM4E (0.41) | KDM4EALDH1A1HSD17B10HPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021050964-A1 | HPK1 ANTAGONISTS AND USES THEREOF | Nimbus Saturn, Inc. (US) | 2021-03-18 | — | — | WO | disclosed |