Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.48 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
| ▸ | BCL2 | P10415 | 1/20 | 0.39 |
| ▸ | F13A1 | P00488 | 1/20 | 0.39 |
| ▸ | TGM2 | P21980 | 1/20 | 0.39 |
| ▸ | TGM1 | P22735 | 1/20 | 0.39 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CTSL | P07711 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23103811 | 0.86 | GRIN2B (0.41) | NAMPTGSK3BDYRK1AGRIN2BBCL2 | |
| SCHEMBL28876581 | 0.86 | GRIN2B (0.41) | NAMPTGSK3BDYRK1AGRIN2BBCL2 | |
| SCHEMBL29736471 | 0.86 | GRIN2B (0.41) | NAMPTGSK3BDYRK1AGRIN2BBCL2 | |
| SCHEMBL22606745 | 0.81 | DEGS1 (0.48) | NAMPTGSK3BDYRK1AGRIN2BBCL2 | |
| SCHEMBL30506468 | 0.81 | DEGS1 (0.48) | NAMPTGSK3BDYRK1AGRIN2BBCL2 | |
| SCHEMBL31726922 | 0.80 | MAPK1 (0.43) | NAMPTGSK3BDYRK1AGRIN2BBCL2 | |
| SCHEMBL16296314 | 0.79 | GSK3B (0.41) | NAMPTGSK3BDYRK1AGRIN2BBCL2 | |
| SCHEMBL28071467 | 0.79 | GSK3B (0.41) | NAMPTGSK3BDYRK1AGRIN2BBCL2 | |
| SCHEMBL24738966 | 0.79 | GSK3B (0.43) | NAMPTGSK3BDYRK1AGRIN2BBCL2 | |
| SCHEMBL27946209 | 0.78 | MAPK1 (0.42) | NAMPTGSK3BDYRK1AGRIN2BBCL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021050964-A1 | HPK1 ANTAGONISTS AND USES THEREOF | Nimbus Saturn, Inc. (US) | 2021-03-18 | — | — | WO | disclosed |