Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CCR4 | P51679 | 8/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.31 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.31 |
| ▸ | AURKA | O14965 | 1/20 | 0.31 |
| ▸ | TTK | P33981 | 1/20 | 0.31 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.31 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.30 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23110907 | 0.82 | CCR4 (0.34) | MAPTKDM4ESMN1; SMN2CCR4MEN1 | |
| SCHEMBL23093236 | 0.75 | FAAH (0.41) | CCR4 | |
| SCHEMBL29802431 | 0.71 | LRRK2 (0.48) | CCR4 | |
| SCHEMBL23093460 | 0.71 | LRRK2 (0.48) | CCR4 | |
| SCHEMBL23093183 | 0.65 | CCR4 (0.40) | CCR4 | |
| SCHEMBL23110919 | 0.65 | CCR4 (0.35) | MAPTKDM4ECCR4 | |
| SCHEMBL5213125 | 0.64 | CNR1 (0.51) | MAPTKDM4ENPC1RAB9AMEN1 | |
| SCHEMBL12924005 | 0.63 | MAPT (0.50) | MAPTKDM4ENPC1PKMRAB9A | |
| SCHEMBL30748324 | 0.63 | MAPT (0.50) | MAPTKDM4ENPC1PKMRAB9A | |
| SCHEMBL13485293 | 0.63 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021050700-A1 | CYCLOOXYGENASE-2 INHIBITORS AND USES THEREOF | THE BROAD INSTITUTE, INC. (US) | 2021-03-18 | — | — | WO | disclosed |