Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | PTGDR2 | Q9Y5Y4 | 6/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | TBXA2R | P21731 | 3/20 | 0.46 |
| ▸ | PTGDR | Q13258 | 3/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.44 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | CASP7 | P55210 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2313013 | 0.96 | KDM4E (0.59) | KDM4ELMNAPTGDR2ALDH1A1L3MBTL1 | |
| SCHEMBL2530097 | 0.85 | KDM4E (0.52) | KDM4ELMNAPTGDR2ALDH1A1L3MBTL1 | |
| SCHEMBL27989288 | 0.83 | KDM4E (0.59) | KDM4ELMNAPTGDR2ALDH1A1L3MBTL1 | |
| SCHEMBL2312645 | 0.82 | KDM4E (0.46) | KDM4ELMNAPTGDR2ALDH1A1L3MBTL1 | |
| SCHEMBL7411338 | 0.82 | KDM4E (0.58) | KDM4ELMNAPTGDR2ALDH1A1L3MBTL1 | |
| Bromide SCHEMBL2430564 | 0.82 | KDM4E (0.58) | KDM4ELMNAPTGDR2ALDH1A1L3MBTL1 | |
| Hydrochloric Acid SCHEMBL27883098 | 0.82 | KDM4E (0.61) | KDM4ELMNAPTGDR2ALDH1A1L3MBTL1 | |
| SCHEMBL2313455 | 0.82 | PTGDR2 (0.51) | KDM4ELMNAPTGDR2ALDH1A1L3MBTL1 | |
| SCHEMBL2313185 | 0.82 | PTGDR2 (0.53) | PTGDR2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL7404475 | 0.81 | KDM4E (0.60) | KDM4ELMNAPTGDR2ALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1833791-B1 | 2,3,4,9-TETRAHYDRO-1H-CARBAZOLE DERIVATIVES AS CRTH2 RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2011-08-03 | — | — | EP | disclosed |
| EP-1833791-A2 | 2,3,4,9-TETRAHYDRO-1H-CARBAZOLE DERIVATIVES AS CRTH2 RECEPTOR ANTAGONISTS | Actelion Pharmaceuticals Ltd. (CH) | 2007-09-19 | — | — | EP | disclosed |
| WO-2006070325-A2 | 2,3,4,9-TETRAHYDRO-1H-CARBAZOLE DERIVATIVES AS CRTH2 RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2006-07-06 | — | — | WO | disclosed |