Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRA | P16234 | 4/20 | 0.36 |
| ▸ | KDR | P35968 | 4/20 | 0.36 |
| ▸ | PYGL | P06737 | 4/20 | 0.32 |
| ▸ | PYGM | P11217 | 4/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 3/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | F13A1 | P00488 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.30 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.30 |
| ▸ | MET | P08581 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2315672 | 0.87 | PDGFRA (0.33) | PDGFRAKDRMAPTLMNA | |
| SCHEMBL4467724 | 0.81 | PDGFRA (0.46) | PDGFRAKDRMAPTLMNAGAA | |
| SCHEMBL4467713 | 0.81 | PDGFRA (0.46) | PDGFRAKDRMAPTLMNAGAA | |
| SCHEMBL2311104 | 0.76 | KDR (0.44) | PDGFRAKDRPYGLPYGMMET | |
| SCHEMBL2311116 | 0.76 | KDR (0.44) | PDGFRAKDRPYGLPYGMMET | |
| SCHEMBL4466297 | 0.74 | PRMT1 (0.49) | PDGFRAKDRMAPTGAAMEN1 | |
| SCHEMBL2315662 | 0.70 | KDR (0.45) | PDGFRAKDRMET | |
| SCHEMBL2932065 | 0.69 | BRAF (0.52) | — | |
| SCHEMBL12616271 | 0.68 | MEN1 (0.44) | PDGFRAKDRMEN1KMT2ARAB9A | |
| SCHEMBL13603235 | 0.67 | PRMT1 (0.51) | PDGFRAKDRMAPTGAAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2531502-A1 | 1-(5-TERT-BUTYL-2-PHENYL-2H-PYRAZOL-3-YL)-3-[2-FLUORO-4-(1-METHYL-2-OXO-2,3-DIHYDRO-1H-IMIDAZO[4,5-B]PYRIDIN-7-YLOXY)-PHENYL]-UREA AND RELATED COMPOUNDS AND THEIR USE IN THERAPY | Cancer Research Technology Limited (GB) | 2012-12-12 | — | — | EP | disclosed |
| WO-2011092469-A1 | 1-(5-TERT-BUTYL-2-PHENYL-2H-PYRAZOL-3-YL)-3-[2-FLUORO-4-(1-METHYL-2-OXO-2,3-DIHYDRO-1H-IMIDAZO[4,5-B]PYRIDIN-7-YLOXY)-PHENYL]-UREA AND RELATED COMPOUNDS AND THEIR USE IN THERAPY | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2011-08-04 | — | — | WO | disclosed |