Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.67 |
| ▸ | BRAF | P15056 | 7/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 7/20 | 0.54 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | RAF1 | P04049 | 2/20 | 0.44 |
| ▸ | ARAF | P10398 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.44 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.42 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.42 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17530357 | 0.93 | TDP1 (0.76) | TDP1BRAFHDAC1MAPTPOLB | |
| SCHEMBL1031276 | 0.93 | TDP1 (0.61) | TDP1BRAFHDAC1RAF1ARAF | |
| SCHEMBL23111302 | 0.90 | TDP1 (0.76) | TDP1BRAFHDAC1MAPTPOLB | |
| SCHEMBL17530348 | 0.88 | BRAF (0.58) | TDP1BRAFHDAC1ABL1RAF1 | |
| SCHEMBL1026867 | 0.87 | TDP1 (0.55) | TDP1BRAFHDAC1RAF1ARAF | |
| SCHEMBL1027039 | 0.85 | TDP1 (0.61) | TDP1BRAFHDAC1RAF1ARAF | |
| SCHEMBL10784720 | 0.85 | TDP1 (0.70) | TDP1MAPTPOLBSIRT6KDM4E | |
| SCHEMBL3512673 | 0.84 | TDP1 (0.62) | TDP1MAPTPOLBSIRT6KDM4E | |
| SCHEMBL1026672 | 0.84 | ALDH1A1 (0.54) | TDP1BRAFHDAC1RAF1ARAF | |
| SCHEMBL30317905 | 0.83 | TDP1 (0.60) | TDP1BRAFHDAC1ABL1RAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3186227-B1 | NOVEL SULFONYLAMINOBENZAMIDE COMPOUNDS AS ANTHELMINTICS | ELANCO TIERGESUNDHEIT AG (CH) | 2021-03-24 | — | — | EP | disclosed |