SCHEMBL23111406

SCHEMBL23111406

Cc1cnc(-c2cc(OC3CCC(=O)N(C)C3)cc(C(=O)NC(C)c3cnc(C(F)(F)F)nc3)c2)s1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
P2RX3 P56373 20/20 1.00
P2RX2 Q9UBL9 20/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17823516 1.00 P2RX3 (1.00) P2RX3P2RX2
SCHEMBL30092101 1.00 P2RX3 (1.00) P2RX3P2RX2
SCHEMBL30091945 0.90 P2RX3 (1.00) P2RX3P2RX2
SCHEMBL23111453 0.90 P2RX3 (1.00) P2RX3P2RX2
SCHEMBL17823551 0.90 P2RX3 (1.00) P2RX3P2RX2
SCHEMBL23111451 0.90 P2RX3 (1.00) P2RX3P2RX2
SCHEMBL17823645 0.90 P2RX3 (1.00) P2RX3P2RX2
SCHEMBL30092211 0.90 P2RX3 (1.00) P2RX3P2RX2
SCHEMBL23111404 0.89 P2RX3 (1.00) P2RX3P2RX2
SCHEMBL30092143 0.89 P2RX3 (1.00) P2RX3P2RX2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110256418-B 1, 3-thiazol-2-yl substituted benzamides 拜耳公司 2023-01-20 CN disclosed
EP-3793553-A1 1,3-THIAZOL-2-YL SUBSTITUTED BENZAMIDES FOR THE TREATMENT OF DISEASES ASSOCIATED WITH NERVE FIBER SENSITIZATION Bayer Aktiengesellschaft (DE) 2021-03-24 EP disclosed
EP-3793554-A1 1,3-THIAZOL-2-YL SUBSTITUTED BENZAMIDES FOR THE TREATMENT OF DISEASES ASSOCIATED WITH NERVE FIBER SENSITIZATION Bayer Aktiengesellschaft (DE) 2021-03-24 EP disclosed
CN-112384213-A 1, 3-thiazol-2-yl substituted benzamides for the treatment of diseases associated with nerve fiber sensitization 拜耳公司 2021-02-19 CN disclosed
CN-112334132-A 1, 3-thiazol-2-yl substituted benzamides for the treatment of diseases associated with nerve fiber sensitization 拜耳公司 2021-02-05 CN disclosed
CN-107207507-B 1, 3-thiazol-2-yl substituted benzamides 拜耳公司 2020-11-06 CN disclosed