Sugi Predict

Sugi Predict / Compounds / SCHEMBL23111464

SCHEMBL23111464

SCHEMBL23111464

Cc1cnc(-c2cc(OC3CCN(C(=O)OC(C)(C)C)CC3)cc(C(=O)NC(C)c3cnc(C(F)(F)F)nc3)c2)s1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
▸ P2RX3 P56373 20/20 1.00
▸ P2RX2 Q9UBL9 20/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29441222 1.00 P2RX3 (1.00) P2RX3P2RX2
SCHEMBL17823855 1.00 P2RX3 (1.00) P2RX3P2RX2
SCHEMBL19962211 0.96 P2RX3 (0.92) P2RX3P2RX2
SCHEMBL23111463 0.94 P2RX3 (1.00) P2RX3P2RX2
SCHEMBL17823505 0.94 P2RX3 (1.00) P2RX3P2RX2
SCHEMBL17823762 0.93 P2RX3 (0.87) P2RX3P2RX2
SCHEMBL21875523 0.93 P2RX3 (0.87) P2RX3P2RX2
SCHEMBL23111422 0.92 P2RX3 (1.00) P2RX3P2RX2
SCHEMBL17823595 0.92 P2RX3 (1.00) P2RX3P2RX2
SCHEMBL19962279 0.92 P2RX3 (1.00) P2RX3P2RX2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110256418-B 1, 3-thiazol-2-yl substituted benzamides 拜耳公司 2023-01-20 — — CN disclosed
EP-3230281-B1 1,3-THIAZOL-2-YL SUBSTITUTED BENZAMIDES BAYER AG (DE) 2021-05-26 — — EP disclosed
EP-3793553-A1 1,3-THIAZOL-2-YL SUBSTITUTED BENZAMIDES FOR THE TREATMENT OF DISEASES ASSOCIATED WITH NERVE FIBER SENSITIZATION Bayer Aktiengesellschaft (DE) 2021-03-24 — — EP disclosed
EP-3793554-A1 1,3-THIAZOL-2-YL SUBSTITUTED BENZAMIDES FOR THE TREATMENT OF DISEASES ASSOCIATED WITH NERVE FIBER SENSITIZATION Bayer Aktiengesellschaft (DE) 2021-03-24 — — EP disclosed
CN-107207507-B 1, 3-thiazol-2-yl substituted benzamides 拜耳公司 2020-11-06 — — CN disclosed