Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 8/20 | 0.60 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | BAZ1A | Q9NRL2 | 1/20 | 0.42 |
| ▸ | PRMT3 | O60678 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23116458 | 1.00 | ROCK2 (0.60) | ROCK2HDAC1ROCK1ALDH1A1BAZ1A | |
| SCHEMBL21359076 | 0.87 | ROCK2 (0.53) | ROCK2HDAC1ROCK1PRMT3 | |
| SCHEMBL21376021 | 0.86 | ROCK2 (0.78) | ROCK2ROCK1 | |
| SCHEMBL23116444 | 0.86 | ROCK2 (0.78) | ROCK2ROCK1 | |
| SCHEMBL21376018 | 0.86 | ROCK2 (0.52) | ROCK2HDAC1ROCK1ALDH1A1BAZ1A | |
| SCHEMBL21359027 | 0.81 | ROCK2 (0.58) | ROCK2HDAC1ROCK1 | |
| SCHEMBL23501352 | 0.78 | ROCK2 (0.78) | ROCK2ROCK1 | |
| SCHEMBL23116449 | 0.76 | MEN1 (0.49) | ROCK2ALDH1A1MEN1LMNAMAPT | |
| SCHEMBL23116448 | 0.76 | MEN1 (0.49) | ROCK2ALDH1A1MEN1LMNAMAPT | |
| SCHEMBL21376079 | 0.76 | ROCK2 (0.60) | ROCK2HDAC1ROCK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210087184-A1 | AMINO-BENZOISOTHIAZOLE AND AMINO-BENZOISOTHIADIAZOLE AMIDE COMPOUNDS | ALCON INC. (CH) | 2021-03-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210087184-A1 | AMINO-BENZOISOTHIAZOLE AND AMINO-BENZOISOTHIADIAZOLE AMIDE COMPOUNDS | ATM, MAP3K15, MAP3K3 | ROCK2 839/4885HDAC1 1276/4885ROCK1 731/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.