Tetrahydrofuran

Tetrahydrofuran

SCHEMBL2311865

C1CCOC1.C=CC(=O)OCCO

nearest known ligand 0.70

Full drug profile on Sugi Atlas →

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
TSHR P16473 7/20 0.70
ALDH1A1 P00352 4/20 0.53
CYP3A4 P08684 2/20 0.53
TP53 P04637 3/20 0.48
HIF1A Q16665 3/20 0.48
HSD17B10 Q99714 1/20 0.48
HPGD P15428 1/20 0.44
MAPK1 P28482 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
THRB P10828 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2492479 0.92 TSHR (0.76) TSHRALDH1A1CYP3A4TP53HIF1A
Oxirane SCHEMBL6686130 0.90 TSHR (0.79) TSHRALDH1A1CYP3A4TP53HIF1A
Cyclopropane SCHEMBL11750295 0.86 TSHR (0.86) TSHRALDH1A1CYP3A4TP53HIF1A
SCHEMBL660331 0.86 TSHR (0.86) TSHRALDH1A1CYP3A4TP53HIF1A
SCHEMBL21630258 0.84 TSHR (1.00) TSHRALDH1A1CYP3A4TP53HIF1A
SCHEMBL30363554 0.84 TSHR (1.00) TSHRALDH1A1CYP3A4TP53HIF1A
SCHEMBL14875 0.84
Dioxane SCHEMBL16105710 0.82 TSHR (0.64) TSHRALDH1A1CYP3A4TP53HIF1A
Ethylene SCHEMBL2946941 0.82 TSHR (0.95) TSHRALDH1A1CYP3A4TP53HIF1A
Ethylene SCHEMBL8850416 0.82 TSHR (0.95) TSHRALDH1A1CYP3A4TP53HIF1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107189252-A The preparation method of polymerizable phosphorus flame retardant and the preparation method of flame-proofed polystyrene 哈尔滨工业大学 2017-09-22 CN claimed
US-8620127-B2 Optical waveguide and method for manufacturing the same HITACHI CHEMICAL COMPANY, LTD. (JP) 2013-12-31 US disclosed
US-20110188827-A1 OPTICAL WAVEGUIDE AND METHOD FOR MANUFACTURING THE SAME HITACHI CHEMICAL COMPANY, LTD. (JP) 2011-08-04 US disclosed
US-6203957-B1 FOR USE IN DEVELOPMENT OF ELECTROSTATIC LATENT IMAGE IN ELECTROPHOTOGRAPHIC PRINTER OR COPIERS; IMAGE QUALITY DIANIPPON INK AND CHEMICALS, INC. (JP) 2001-03-20 US disclosed
US-6183924-B1 FOR USE IN DEVELOPMENT OF ELECTROSTATIC IMAGE IN ELECTROPHOTOGRAPHIC COPYING MACHINES OR PRINTERS; IMAGE QUALITY; LESS USE OF TONER PER SHEET OF PRINTING PAPER DAIMIPPON INK AND CHEMICALS, INC. (JP) 2001-02-06 US disclosed
US-6127083-A SUPPLYING SPHERICALLY PARTICULATE TONER DEVELOPER ONTO PHOTORECEPTOR USING NON-MAGNETIC ONE-COMPONENT DEVELOPING MACHINE COMPRISING DEVELOPER-SUPPORTING ROLL AND LAYER-FORMING BLADE TO DEVELOP ELECTROSTATIC LATENT IMAGE DAINIPPON INK AND CHEMICALS, INC. (JP) 2000-10-03 US disclosed