Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 19/20 | 0.65 |
| ▸ | HPGDS | O60760 | 2/20 | 0.54 |
| ▸ | DDB1 | Q16531 | 9/20 | 0.51 |
| ▸ | AR | P10275 | 5/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.47 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | BTK | Q06187 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29098484 | 0.87 | CRBN (0.65) | CRBNHPGDSDDB1ARALDH1A1 | |
| SCHEMBL25216081 | 0.86 | CRBN (0.69) | CRBNHPGDSDDB1ARALDH1A1 | |
| SCHEMBL22661301 | 0.84 | CRBN (0.58) | CRBNHPGDSDDB1AR | |
| SCHEMBL29098531 | 0.83 | CRBN (0.64) | CRBNHPGDSDDB1ARALDH1A1 | |
| SCHEMBL20046280 | 0.82 | CRBN (0.63) | CRBNHPGDSDDB1ARBTK | |
| SCHEMBL29878029 | 0.82 | CRBN (0.63) | CRBNHPGDSDDB1ARBTK | |
| SCHEMBL30441421 | 0.82 | CRBN (0.65) | CRBNHPGDSDDB1ARALDH1A1 | |
| SCHEMBL25201176 | 0.82 | CRBN (0.65) | CRBNHPGDSDDB1ARALDH1A1 | |
| SCHEMBL22661369 | 0.82 | CRBN (0.65) | CRBNHPGDSDDB1ALDH1A1CHRM2 | |
| SCHEMBL30312927 | 0.82 | CRBN (0.65) | CRBNHPGDSDDB1ALDH1A1CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021061204-A1 | NOVEL SUBSTITUTED QUINOLINE-8-CARBONITRILE DERIVATIVES HAVING ANDROGEN RECEPTOR DEGRADATION ACTIVITY AND USES THEREOF | ACCUTAR BIOTECHNOLOGY INC. (US) | 2021-04-01 | — | — | WO | disclosed |
| WO-2021061644-A1 | NOVEL SUBSTITUTED QUINOLINE-8-CARBONITRILE DERIVATIVES WITH ANDROGEN RECEPTOR DEGRADATION ACTIVITY AND USES THEREOF | ACCUTAR BIOTECHNOLOGY INC. (US) | 2021-04-01 | — | — | WO | disclosed |
| EP-3795570-A1 | SUBSTITUTED QUINOLINE-8-CARBONITRILE DERIVATIVES HAVING ANDROGEN RECEPTOR DEGRADATION ACTIVITY AND USES THEREOF | Accutar Biotechnology Inc. (US) | 2021-03-24 | — | — | EP | disclosed |