Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 19/20 | 0.65 |
| ▸ | HPGDS | O60760 | 2/20 | 0.52 |
| ▸ | DDB1 | Q16531 | 8/20 | 0.52 |
| ▸ | AR | P10275 | 6/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.47 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | BTK | Q06187 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29546958 | 0.88 | CRBN (0.54) | CRBNHPGDSDDB1ARALDH1A1 | |
| SCHEMBL24379104 | 0.88 | CRBN (0.54) | CRBNHPGDSDDB1ARALDH1A1 | |
| SCHEMBL23129061 | 0.87 | CRBN (0.65) | CRBNHPGDSDDB1ARALDH1A1 | |
| SCHEMBL25216081 | 0.84 | CRBN (0.69) | CRBNHPGDSDDB1ARALDH1A1 | |
| SCHEMBL25201176 | 0.84 | CRBN (0.65) | CRBNHPGDSDDB1ARALDH1A1 | |
| SCHEMBL30441421 | 0.84 | CRBN (0.65) | CRBNHPGDSDDB1ARALDH1A1 | |
| SCHEMBL22692246 | 0.83 | CRBN (0.53) | CRBNHPGDSDDB1ARALDH1A1 | |
| SCHEMBL20046778 | 0.82 | CRBN (0.56) | CRBNHPGDSDDB1ARALDH1A1 | |
| SCHEMBL29223473 | 0.82 | CRBN (0.69) | CRBNHPGDSDDB1ARALDH1A1 | |
| SCHEMBL30692984 | 0.82 | CRBN (0.62) | CRBNHPGDSDDB1ALDH1A1CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4146660-A1 | BIFUNCTIONAL DEGRADERS OF HEMATOPOIETIC PROGENITOR KINASE AND THERAPEUTIC USES THEREOF | Nurix Therapeutics, Inc. (US) | 2023-03-15 | — | — | EP | disclosed |
| CN-115605488-A | Bifunctional degradants of hematopoietic progenitor kinases and therapeutic uses thereof | 新锐思生物制药股份有限公司（US） | 2023-01-13 | — | — | CN | disclosed |