Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.40 |
| ▸ | SYK | P43405 | 2/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.36 |
| ▸ | MGLL | Q99685 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | PRKDC | P78527 | 1/20 | 0.34 |
| ▸ | MERTK | Q12866 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23132890 | 1.00 | HRH3 (0.40) | HRH3SYKCHRNB2CHRNA4MGLL | |
| SCHEMBL23108878 | 1.00 | HRH3 (0.40) | HRH3SYKCHRNB2CHRNA4MGLL | |
| SCHEMBL23108681 | 1.00 | HRH3 (0.40) | HRH3SYKCHRNB2CHRNA4MGLL | |
| SCHEMBL23103856 | 0.88 | HRH3 (0.49) | HRH3MAPT | |
| SCHEMBL23107223 | 0.88 | HRH3 (0.49) | HRH3MAPT | |
| SCHEMBL23707108 | 0.83 | NPC1 (0.40) | HRH3SYKCHRNB2CHRNA4MGLL | |
| SCHEMBL23107214 | 0.82 | PRKDC (0.35) | HRH3SYKCHRNB2CHRNA4MGLL | |
| SCHEMBL23089168 | 0.82 | PIK3CA (0.37) | HRH3SYKCHRNB2CHRNA4PRKDC | |
| SCHEMBL23103153 | 0.82 | PRKDC (0.35) | HRH3SYKCHRNB2CHRNA4MGLL | |
| SCHEMBL23103163 | 0.82 | PRKDC (0.35) | HRH3SYKCHRNB2CHRNA4MGLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210087190-A1 | SUBSTITUTED ISOINDOLIN-1-ONES AND 2,3-DIHYDRO-1H-PYRROLO[3,4-c]PYRIDIN-1-ONES AS HPK1 ANTAGONISTS | CHARLES RIVER DISCOVERY RESEARCH SERVICES UK LIMITED (GB) | 2021-03-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210087190-A1 | SUBSTITUTED ISOINDOLIN-1-ONES AND 2,3-DIHYDRO-1H-PYRROLO[3,4-c]PYRIDIN-1-ONES AS HPK1 ANTAGONISTS | HIPK1, PDXK, IP6K1 | HRH3 303/4885SYK 4455/4885CHRNB2 1400/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.