SCHEMBL2313461

SCHEMBL2313461

O=Cc1c(Cl)sc2cncnc12

nearest known ligand 0.35

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 2/20 0.33
IRAK4 Q9NWZ3 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17917464 0.70 EGFR (0.31)
SCHEMBL29805674 0.65
SCHEMBL6926441 0.65 CLK1 (0.36) CYP2A6
SCHEMBL17040448 0.64
SCHEMBL359834 0.64 CYP2A6 (0.39) CYP2A6IRAK4
SCHEMBL29947362 0.64 CYP2A6 (0.39) CYP2A6IRAK4
SCHEMBL28322375 0.62 MEN1 (0.39)
SCHEMBL29805713 0.61 CYP2A6 (0.50) CYP2A6
SCHEMBL27617985 0.61 CYP2A6 (0.50) CYP2A6
SCHEMBL4302108 0.61 IRAK4 (0.39) IRAK4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2528925-A2 THIENO[3,2-d]PYRIMIDINE DERIVATIVES HAVING INHIBITORY ACTIVITY ON PROTEIN KINASES Hanmi Science Co., Ltd. (KR) 2012-12-05 EP disclosed
WO-2011093684-A2 THIENO[3,2-d]PYRIMIDINE DERIVATIVES HAVING INHIBITORY ACTIVITY ON PROTEIN KINASES HANMI HOLDINGS CO., LTD. (KR) 2011-08-04 WO disclosed