Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.36 |
| ▸ | TLR9 | Q9NR96 | 3/20 | 0.32 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.32 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.32 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.32 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22305194 | 0.84 | HRH3 (0.38) | HRH3KCNH2KDM4EALDH1A1PKM | |
| SCHEMBL24233173 | 0.81 | ACHE (0.44) | ACHEHRH3TLR9TLR8TLR7 | |
| SCHEMBL22520769 | 0.80 | CHRM5 (0.43) | ACHEHRH3TLR9TLR8TLR7 | |
| SCHEMBL26263465 | 0.79 | SMN1; SMN2 (0.42) | SMN1; SMN2ACHEHRH3POLBKCNH2 | |
| SCHEMBL25075217 | 0.79 | SMN1; SMN2 (0.42) | SMN1; SMN2ACHEHRH3POLBKCNH2 | |
| SCHEMBL25482583 | 0.79 | ACHE (0.42) | ACHEHRH3TLR9TLR8TLR7 | |
| SCHEMBL14453909 | 0.79 | CHRM5 (0.41) | ACHEHRH3TLR9TLR8TLR7 | |
| SCHEMBL23484949 | 0.78 | ACHE (0.60) | ACHEHRH3TLR9TLR8TLR7 | |
| SCHEMBL26497170 | 0.78 | ACHE (0.41) | ACHEHRH3TLR9TLR8TLR7 | |
| SCHEMBL24548062 | 0.77 | HRH3 (0.39) | ACHEHRH3CHRM5ADRA2CKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021055295-A1 | BRD9 BIFUNCTIONAL DEGRADERS AND THEIR METHODS OF USE | NOVARTIS AG (CH) | 2021-03-25 | — | — | WO | disclosed |