Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHR | P35869 | 1/20 | 0.44 |
| ▸ | CCNB2 | O95067 | 6/20 | 0.43 |
| ▸ | CDK1 | P06493 | 6/20 | 0.43 |
| ▸ | CCNB1 | P14635 | 6/20 | 0.43 |
| ▸ | CCNB3 | Q8WWL7 | 6/20 | 0.43 |
| ▸ | CDK5 | Q00535 | 12/20 | 0.41 |
| ▸ | CDK5R1 | Q15078 | 12/20 | 0.41 |
| ▸ | CDK2 | P24941 | 10/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 6/20 | 0.41 |
| ▸ | CCNA1 | P78396 | 6/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 6/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.40 |
| ▸ | CDK9 | P50750 | 2/20 | 0.40 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.40 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.39 |
| ▸ | CDK7 | P50613 | 1/20 | 0.39 |
| ▸ | CCNH | P51946 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2315103 | 0.85 | AHR (0.58) | AHRCCNB2CDK1CCNB1CCNB3 | |
| SCHEMBL2313618 | 0.82 | CDK1 (0.47) | AHRCCNB2CDK1CCNB1CCNB3 | |
| SCHEMBL24966401 | 0.79 | CDK5 (0.42) | CCNB2CDK1CCNB1CCNB3CDK5 | |
| SCHEMBL2315311 | 0.78 | AHR (0.51) | AHRCCNB2CDK1CCNB1CCNB3 | |
| SCHEMBL2312171 | 0.78 | CDK2 (0.46) | AHRCCNB2CDK1CCNB1CCNB3 | |
| SCHEMBL21754116 | 0.76 | CDK2 (0.38) | AHRCCNB2CDK1CCNB1CCNB3 | |
| SCHEMBL15013506 | 0.75 | AHR (0.59) | AHRCCNB2CDK1CCNB1CCNB3 | |
| SCHEMBL21016789 | 0.75 | AHR (0.59) | AHRCCNB2CDK1CCNB1CCNB3 | |
| SCHEMBL2314403 | 0.75 | AHR (0.59) | AHRCCNB2CDK1CCNB1CCNB3 | |
| SCHEMBL3242817 | 0.75 | ITGB1 (0.46) | AHRCCNB2CDK1CCNB1CCNB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2350078-A2 | COMPOUNDS THAT EXPAND HEMATOPOIETIC STEM CELLS | IRM LLC (BM) | 2011-08-03 | — | — | EP | claimed |
| WO-2010059401-A2 | COMPOUNDS THAT EXPAND HEMATOPOIETIC STEM CELLS | IRM LLC (BM) | 2010-05-27 | — | — | WO | claimed |
| EP-2788476-A1 | COMPOSITIONS AND METHODS FOR ENHANCED GENERATION OF HEMATOPOIETIC STEM/PROGENITOR CELLS | Fred Hutchinson Cancer Research Center (US) | 2014-10-15 | — | — | EP | disclosed |
| WO-2013086436-A1 | COMPOSITIONS AND METHODS FOR ENHANCED GENERATION OF HEMATOPOIETIC STEM/PROGENITOR CELLS | FRED HUTCHINSON CANCER RESEARCH CENTER (US) | 2013-06-13 | — | — | WO | disclosed |
| EP-2350078-A2 | COMPOUNDS THAT EXPAND HEMATOPOIETIC STEM CELLS | IRM LLC (BM) | 2011-08-03 | — | — | EP | disclosed |
| WO-2010059401-A2 | COMPOUNDS THAT EXPAND HEMATOPOIETIC STEM CELLS | IRM LLC (BM) | 2010-05-27 | — | — | WO | disclosed |