Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK5 | Q00535 | 19/20 | 0.42 |
| ▸ | CDK5R1 | Q15078 | 19/20 | 0.42 |
| ▸ | CCNB2 | O95067 | 6/20 | 0.42 |
| ▸ | CDK1 | P06493 | 6/20 | 0.42 |
| ▸ | CCNB1 | P14635 | 6/20 | 0.42 |
| ▸ | CCNB3 | Q8WWL7 | 6/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 11/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 11/20 | 0.42 |
| ▸ | CDK2 | P24941 | 11/20 | 0.42 |
| ▸ | CCNA1 | P78396 | 11/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21016614 | 0.88 | PDE4A (0.38) | CDK5CDK5R1CCNB2CDK1CCNB1 | |
| SCHEMBL20542038 | 0.83 | CDK5 (0.41) | CDK5CDK5R1CCNB2CDK1CCNB1 | |
| SCHEMBL30579323 | 0.83 | CDK2 (0.53) | CDK5CDK5R1CDK1CCNB1DYRK1A | |
| SCHEMBL30579367 | 0.83 | CDK5 (0.41) | CDK5CDK5R1CCNB2CDK1CCNB1 | |
| SCHEMBL2315103 | 0.80 | AHR (0.58) | CDK5CDK5R1CCNB2CDK1CCNB1 | |
| SCHEMBL24966413 | 0.79 | CDK2 (0.38) | CDK5CDK5R1CDK1CCNB1DYRK1A | |
| SCHEMBL2315980 | 0.79 | CDK2 (0.50) | CDK5CDK5R1CCNB2CDK1CCNB1 | |
| SCHEMBL2313622 | 0.79 | AHR (0.44) | CDK5CDK5R1CCNB2CDK1CCNB1 | |
| SCHEMBL2313618 | 0.79 | CDK1 (0.47) | CDK5CDK5R1CCNB2CDK1CCNB1 | |
| SCHEMBL2315311 | 0.78 | AHR (0.51) | CDK5CDK5R1CCNB2CDK1CCNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230028336-A1 | INDOLE AHR INHIBITORS AND USES THEREOF | PAHR THERAPEUTICS, INC. | 2023-01-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230028336-A1 | INDOLE AHR INHIBITORS AND USES THEREOF | AHR, ARNT, IDO1 | CDK5 1931/4885CDK5R1 1393/4885CCNB2 3779/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.