Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 3/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.31 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.31 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27866260 | 0.80 | MEN1 (0.38) | MEN1KMT2AGAAKDM4EMAPT | |
| SCHEMBL28241689 | 0.78 | MEN1 (0.37) | MEN1KMT2AGAAKDM4EMAPT | |
| SCHEMBL26418640 | 0.76 | MEN1 (0.36) | MEN1KMT2AGAAKDM4EMAPT | |
| SCHEMBL27648939 | 0.73 | MEN1 (0.34) | MEN1KMT2AGAAKDM4EMAPT | |
| SCHEMBL2700796 | 0.73 | MEN1 (0.34) | MEN1KMT2AGAAKDM4EMAPT | |
| SCHEMBL23588021 | 0.73 | MEN1 (0.34) | MEN1KMT2AGAAKDM4EMAPT | |
| SCHEMBL28045542 | 0.73 | ALDH1A1 (0.36) | MEN1KMT2AGAAKDM4EMAPT | |
| SCHEMBL20033485 | 0.73 | ALDH1A1 (0.36) | MEN1KMT2AGAAKDM4EMAPT | |
| SCHEMBL23138192 | 0.72 | — | — | |
| SCHEMBL23989843 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021055589-A1 | HETEROARYL PLASMA KALLIKREIN INHIBITORS | SHIRE HUMAN GENETIC THERAPIES, INC. (US) | 2021-03-25 | — | — | WO | disclosed |