Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | HTR2B | P41595 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.41 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.41 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 3/20 | 0.40 |
| ▸ | CA12 | O43570 | 2/20 | 0.40 |
| ▸ | CA1 | P00915 | 2/20 | 0.40 |
| ▸ | CA9 | Q16790 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25509852 | 0.85 | CA12 (0.53) | ALDH1A1KMT2ATRPA1LMNACHRM1 | |
| SCHEMBL23139479 | 0.83 | GAA (0.47) | ALDH1A1KMT2ATRPA1LMNACHRM1 | |
| SCHEMBL25494265 | 0.83 | NPC1 (0.51) | ALDH1A1KMT2ATRPA1LMNACHRM1 | |
| SCHEMBL11541781 | 0.82 | ALDH1A1 (0.46) | ALDH1A1KMT2ALMNAMAPTKDM4E | |
| SCHEMBL11542209 | 0.82 | ALDH1A1 (0.46) | ALDH1A1KMT2ALMNAGAAMAPT | |
| SCHEMBL25495313 | 0.81 | KMT2A (0.53) | ALDH1A1KMT2ATRPA1LMNACHRM1 | |
| SCHEMBL13804531 | 0.80 | ALDH1A1 (0.55) | ALDH1A1KMT2AMAPTKDM4EHPGD | |
| SCHEMBL23139488 | 0.80 | SMN1; SMN2 (0.49) | TRPA1LMNACHRM1SLC6A2ADRA1A | |
| SCHEMBL25494277 | 0.79 | GAA (0.64) | ALDH1A1KMT2ATRPA1LMNACHRM1 | |
| SCHEMBL24599223 | 0.78 | S1PR1 (0.59) | ALDH1A1LMNACHRM1ADRA1AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12029791-B2 | Therapeutic conjugates | TOTUS MEDICINES INC. (US) | 2024-07-09 | — | — | US | disclosed |
| WO-2024086664-A2 | COVALENT INHIBITORS OF WILD-TYPE AND MUTANT PI3K AND METHOD OF USES THEREOF | TOTUS MEDICINES INC. (US) | 2024-04-25 | — | — | WO | disclosed |
| WO-2023183936-A2 | COMBINATION THERAPY OF A PI3K INHIBITOR AND KRAS INHIBITOR AND METHODS OF USE THEREOF | TOTUS MEDICINES INC. (US) | 2023-09-28 | — | — | WO | disclosed |
| US-20220387603-A1 | THERAPEUTIC CONJUGATES | TOTUS MEDICINES INC. | 2022-12-08 | — | — | US | disclosed |
| WO-2021055747-A1 | THERAPEUTIC CONJUGATES | TOTUS MEDICINES INC. (US) | 2021-03-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12029791-B2 | Therapeutic conjugates | CD47, CD44, EPCAM | ALDH1A1 1307/4885KMT2A 2318/4885TRPA1 4885/4885 |
| US-20220387603-A1 | THERAPEUTIC CONJUGATES | CD47, CD44, EPCAM | ALDH1A1 1307/4885KMT2A 2318/4885TRPA1 4885/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.