Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | AKR1C3 | P42330 | 5/20 | 0.52 |
| ▸ | AKR1C2 | P52895 | 5/20 | 0.52 |
| ▸ | POLB | P06746 | 4/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.46 |
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30938277 | 1.00 | SMN1; SMN2 (0.54) | SMN1; SMN2AKR1C3AKR1C2POLBKDM4E | |
| SCHEMBL1983309 | 0.88 | AKR1C3 (0.53) | SMN1; SMN2AKR1C3AKR1C2POLBKDM4E | |
| SCHEMBL30938349 | 0.85 | KDM4E (0.59) | SMN1; SMN2AKR1C3AKR1C2KDM4ELMNA | |
| SCHEMBL30938335 | 0.85 | MAPK10 (0.50) | SMN1; SMN2KDM4ELMNAMAPTGAA | |
| SCHEMBL309309 | 0.84 | SMN1; SMN2 (0.56) | SMN1; SMN2AKR1C3AKR1C2POLBKDM4E | |
| SCHEMBL11001664 | 0.83 | ALDH1A1 (0.65) | POLBALDH1A1KMT2A | |
| SCHEMBL23352159 | 0.82 | LIMK1 (0.46) | SMN1; SMN2AKR1C3AKR1C2KDM4ELMNA | |
| SCHEMBL694237 | 0.80 | POLB (0.53) | AKR1C3POLBKDM4EMEN1KMT2A | |
| SCHEMBL8978047 | 0.80 | POLB (0.45) | SMN1; SMN2AKR1C2POLBLMNAMEN1 | |
| SCHEMBL25568108 | 0.80 | GAA (0.43) | SMN1; SMN2AKR1C3AKR1C2KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3551633-B1 | SUBSTITUTED PYRAZOLOAZEPIN-4-ONES AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS | LEO PHARMA AS (DK) | 2021-03-31 | — | — | EP | claimed |