Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 5/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | NAAA | Q02083 | 1/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | LIPG | Q9Y5X9 | 3/20 | 0.38 |
| ▸ | ENPP2 | Q13822 | 3/20 | 0.38 |
| ▸ | ATXN2 | Q99700 | 3/20 | 0.38 |
| ▸ | LTC4S | Q16873 | 1/20 | 0.37 |
| ▸ | LPL | P06858 | 2/20 | 0.36 |
| ▸ | LIPC | P11150 | 2/20 | 0.36 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.36 |
| ▸ | MGLL | Q99685 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL23149380 | 1.00 | SLC6A4 (0.44) | SLC6A4SLC6A2SLC6A3IDO1NAAA | |
| SCHEMBL23105361 | 0.92 | SLC6A4 (0.50) | SLC6A4SLC6A2SLC6A3IDO1NAAA | |
| SCHEMBL30700758 | 0.92 | SLC6A4 (0.50) | SLC6A4SLC6A2SLC6A3IDO1NAAA | |
| SCHEMBL23105360 | 0.92 | SLC6A4 (0.50) | SLC6A4SLC6A2SLC6A3IDO1NAAA | |
| Trifluoroacetic Acid SCHEMBL26649036 | 0.90 | NAAA (0.41) | SLC6A4SLC6A2SLC6A3IDO1NAAA | |
| Trifluoroacetic Acid SCHEMBL29569486 | 0.90 | NAAA (0.41) | SLC6A4SLC6A2SLC6A3IDO1NAAA | |
| Trifluoroacetic Acid SCHEMBL23091803 | 0.84 | NAAA (0.43) | SLC6A4SLC6A2SLC6A3IDO1NAAA | |
| Trifluoroacetic Acid SCHEMBL23152297 | 0.84 | IDO1 (0.47) | SLC6A4SLC6A2SLC6A3IDO1NAAA | |
| SCHEMBL23105362 | 0.81 | IDO1 (0.47) | SLC6A4SLC6A2SLC6A3IDO1NAAA | |
| SCHEMBL31308833 | 0.81 | IDO1 (0.49) | SLC6A4SLC6A2SLC6A3IDO1NAAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220275005-A1 | HETEROCYCLIC COMPOUNDS | HOFFMANN-LA ROCHE INC. (US) | 2022-09-01 | — | — | US | disclosed |
| EP-4028401-A1 | 4,4A,5,7,8,8A-HEXAPYRIDO[4,3-B][1,4]OXAZIN-3-ONE COMPOUNDS AS MAGL INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2022-07-20 | — | — | EP | disclosed |
| CN-114364682-A | Compound 4,4A,5,7,8, 8A-hexapyrido [4,3-B ] [1,4] oxazin-3-one as MAGL inhibitor | 豪夫迈·罗氏有限公司 | 2022-04-15 | — | — | CN | disclosed |
| US-20210094971-A1 | HETEROCYCLIC COMPOUNDS | HOFFMANN-LA ROCHE INC. (US) | 2021-04-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210094971-A1 | HETEROCYCLIC COMPOUNDS | CYP1B1, CYP4B1, CYP4X1 | SLC6A4 4287/4885SLC6A2 4539/4885SLC6A3 4556/4885 |
| US-20220275005-A1 | HETEROCYCLIC COMPOUNDS | CYP1B1, CYP4B1, CYP4X1 | SLC6A4 4287/4885SLC6A2 4539/4885SLC6A3 4556/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.