SCHEMBL2315093

SCHEMBL2315093

CCOC(=O)C(C(=O)OCC)[C@@H]1CC[C@@H](N)[C@H](c2ccc(C(F)(F)F)cc2)C1

nearest known ligand 0.42

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
MAOB P27338 3/20 0.42
MAOA P21397 1/20 0.42
ATM Q13315 1/20 0.39
HTR2C P28335 1/20 0.39
KDM4E B2RXH2 2/20 0.38
ALDH1A1 P00352 2/20 0.38
POLB P06746 2/20 0.38
GAA P10253 1/20 0.38
MAPK1 P28482 1/20 0.38
TDP1 Q9NUW8 1/20 0.38
MAPT P10636 1/20 0.38
ACHE P22303 1/20 0.37
KDM1A O60341 3/20 0.37
NPSR1 Q6W5P4 1/20 0.36
P2RY14 Q15391 3/20 0.36
EPHX2 P34913 1/20 0.36
PPARG P37231 1/20 0.36
SLC18A2 Q05940 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13836670 0.83 MAOB (0.46) MAOBMAOAHTR2CKDM1AP2RY14
SCHEMBL2314346 0.79 MAOB (0.45) MAOBMAOAHTR2CKDM4EALDH1A1
SCHEMBL2364189 0.79 MAOB (0.45) MAOBMAOAHTR2CKDM4EALDH1A1
SCHEMBL6918804 0.72 KDM4E (0.45) MAOBMAOAHTR2CKDM4EALDH1A1
SCHEMBL6082093 0.71 KDM4E (0.47) ATMHTR2CKDM4EALDH1A1MAPT
SCHEMBL1800153 0.71 KDM4E (0.47) ATMHTR2CKDM4EALDH1A1MAPT
SCHEMBL1798877 0.71 KDM4E (0.47) ATMHTR2CKDM4EALDH1A1MAPT
SCHEMBL2934392 0.71 KDM4E (0.47) ATMHTR2CKDM4EALDH1A1MAPT
SCHEMBL1799795 0.71 KDM4E (0.47) ATMHTR2CKDM4EALDH1A1MAPT
SCHEMBL13836451 0.71 P2RY14 (0.46) MAOBMAOAHTR2CKDM1AP2RY14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011092611-A1 AMINOCYCLOHEXANES AND AMINOTETRAHYDROPYRANS AND RELATED COMPOUNDS AS GAMMA-SECRETASE MODULATORS PFIZER INC. (US) 2011-08-04 WO disclosed