Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 11/20 | 0.45 |
| ▸ | MAOA | P21397 | 9/20 | 0.45 |
| ▸ | KDM1A | O60341 | 10/20 | 0.40 |
| ▸ | P2RY14 | Q15391 | 4/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | RCOR1 | Q9UKL0 | 3/20 | 0.39 |
| ▸ | KDM1B | Q8NB78 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2314346 | 1.00 | MAOB (0.45) | MAOBMAOAKDM1AP2RY14HTR2C | |
| SCHEMBL13836670 | 0.87 | MAOB (0.46) | MAOBMAOAKDM1AP2RY14HTR2C | |
| SCHEMBL2365228 | 0.86 | KDM1A (0.50) | MAOBMAOAKDM1ARCOR1KDM1B | |
| SCHEMBL2315093 | 0.79 | MAOB (0.42) | MAOBMAOAKDM1AP2RY14HTR2C | |
| SCHEMBL2320306 | 0.78 | PSEN1 (0.39) | — | |
| SCHEMBL2320390 | 0.78 | PSEN1 (0.39) | — | |
| SCHEMBL6917440 | 0.78 | PSEN1 (0.39) | — | |
| SCHEMBL2315950 | 0.77 | KDM1A (0.43) | MAOBMAOAKDM1ARCOR1 | |
| SCHEMBL2317616 | 0.77 | PSEN1 (0.35) | — | |
| SCHEMBL4509426 | 0.75 | P2RY14 (0.39) | KDM1AP2RY14HTR2CKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011092611-A1 | AMINOCYCLOHEXANES AND AMINOTETRAHYDROPYRANS AND RELATED COMPOUNDS AS GAMMA-SECRETASE MODULATORS | PFIZER INC. (US) | 2011-08-04 | — | — | WO | disclosed |