Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.45 |
| ▸ | NPY1R | P25929 | 1/20 | 0.45 |
| ▸ | NPY2R | P49146 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | STAT3 | P40763 | 1/20 | 0.44 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23152190 | 1.00 | KDM4E (0.47) | KDM4EMAPTNPSR1TDP1RAB9A | |
| SCHEMBL23486541 | 0.88 | RAB9A (0.62) | KDM4EMAPTNPSR1TDP1RAB9A | |
| SCHEMBL2995178 | 0.86 | SLC7A5 (0.56) | RAB9ANPC1SLC7A5STAT3CYP3A4 | |
| SCHEMBL2995175 | 0.86 | SLC7A5 (0.56) | RAB9ANPC1SLC7A5STAT3CYP3A4 | |
| SCHEMBL23486477 | 0.85 | HDAC8 (0.48) | KDM4EMAPTNPSR1TDP1RAB9A | |
| Hydrochloric Acid SCHEMBL23466585 | 0.85 | SLC7A5 (0.55) | RAB9ANPC1KMT2AMEN1SLC7A5 | |
| SCHEMBL23176696 | 0.84 | MEN1 (0.50) | MAPTNPSR1RAB9ANPC1KMT2A | |
| SCHEMBL23486795 | 0.82 | CYP3A4 (0.50) | KDM4EMAPTNPSR1TDP1KMT2A | |
| SCHEMBL18444718 | 0.82 | HDAC8 (0.50) | KDM4EMAPTNPSR1TDP1RAB9A | |
| SCHEMBL7299745 | 0.81 | MEN1 (0.51) | NPSR1RAB9ANPC1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116120240-A | FXIa inhibitor compound, preparation method and medical application thereof | 深圳信立泰药业股份有限公司 | 2023-05-16 | — | — | CN | disclosed |
| CN-114206854-B | FXIa inhibitor and preparation method and medical application thereof | 深圳信立泰药业股份有限公司 | 2023-02-24 | — | — | CN | disclosed |
| CN-114206854-A | FXIa inhibitor and preparation method and medical application thereof | 深圳信立泰药业股份有限公司 | 2022-03-18 | — | — | CN | disclosed |
| WO-2021057818-A1 | FXIA INHIBITORS AND PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | 深圳信立泰药业股份有限公司 | 2021-04-01 | — | — | WO | disclosed |