Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 9/20 | 0.51 |
| ▸ | JAK2 | O60674 | 3/20 | 0.43 |
| ▸ | JAK1 | P23458 | 3/20 | 0.43 |
| ▸ | TYK2 | P29597 | 2/20 | 0.43 |
| ▸ | JAK3 | P52333 | 2/20 | 0.43 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | CCR2 | P41597 | 2/20 | 0.40 |
| ▸ | AXL | P30530 | 1/20 | 0.40 |
| ▸ | CCNK | O75909 | 1/20 | 0.40 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21714364 | 1.00 | HSD11B1 (0.51) | HSD11B1JAK2JAK1TYK2JAK3 | |
| SCHEMBL21714313 | 1.00 | HSD11B1 (0.51) | HSD11B1JAK2JAK1TYK2JAK3 | |
| SCHEMBL20111931 | 0.88 | HSD11B1 (0.54) | HSD11B1JAK2JAK1TYK2JAK3 | |
| SCHEMBL20111934 | 0.84 | HSD11B1 (0.53) | HSD11B1JAK2JAK1TYK2JAK3 | |
| SCHEMBL21714519 | 0.83 | HSD11B1 (0.55) | HSD11B1JAK2JAK1TYK2JAK3 | |
| SCHEMBL12509445 | 0.83 | HSD11B1 (0.69) | HSD11B1JAK2JAK1TYK2JAK3 | |
| SCHEMBL2267177 | 0.82 | HSD11B1 (0.63) | HSD11B1JAK2JAK1TYK2JAK3 | |
| SCHEMBL21714083 | 0.82 | HSD11B1 (0.51) | HSD11B1JAK2JAK1TYK2JAK3 | |
| SCHEMBL21714117 | 0.81 | HSD11B1 (0.54) | HSD11B1JAK2JAK1TYK2JAK3 | |
| SCHEMBL20792300 | 0.81 | HSD11B1 (0.49) | HSD11B1JAK2JAK1TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10961238-B2 | Modulators of hedgehog (Hh) signaling pathway | E-THERAPEUTICS PLC (GB) | 2021-03-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10961238-B2 | Modulators of hedgehog (Hh) signaling pathway | SHH, GLI1, SMO | HSD11B1 1272/4885JAK2 143/4885JAK1 119/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.