Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 9/20 | 0.56 |
| ▸ | OPRL1 | P41146 | 4/20 | 0.51 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.51 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.51 |
| ▸ | CCR2 | P41597 | 5/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21714144 | 0.90 | HSD11B1 (0.52) | HSD11B1OPRL1OPRM1OPRK1CCR2 | |
| SCHEMBL21714579 | 0.89 | HSD11B1 (0.54) | HSD11B1OPRL1OPRM1OPRK1CCR2 | |
| SCHEMBL21714479 | 0.89 | HSD11B1 (0.54) | HSD11B1OPRL1OPRM1OPRK1CCR2 | |
| SCHEMBL21714473 | 0.88 | HSD11B1 (0.53) | HSD11B1OPRL1OPRM1OPRK1CCR2 | |
| SCHEMBL21714584 | 0.88 | HSD11B1 (0.53) | HSD11B1OPRL1OPRM1OPRK1CCR2 | |
| SCHEMBL21714614 | 0.88 | HSD11B1 (0.53) | HSD11B1OPRL1OPRM1OPRK1CCR2 | |
| SCHEMBL21714277 | 0.88 | HSD11B1 (0.59) | HSD11B1OPRL1OPRM1OPRK1CCR2 | |
| SCHEMBL21714477 | 0.88 | HSD11B1 (0.53) | HSD11B1OPRL1OPRM1OPRK1CCR2 | |
| SCHEMBL21714306 | 0.88 | HSD11B1 (0.53) | HSD11B1OPRL1OPRM1OPRK1CCR2 | |
| SCHEMBL20112192 | 0.88 | HSD11B1 (0.53) | HSD11B1OPRL1OPRM1OPRK1CCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10961238-B2 | Modulators of hedgehog (Hh) signaling pathway | E-THERAPEUTICS PLC (GB) | 2021-03-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10961238-B2 | Modulators of hedgehog (Hh) signaling pathway | SHH, GLI1, SMO | HSD11B1 1272/4885OPRL1 3722/4885OPRM1 2285/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.