Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCD | O00767 | 3/20 | 0.56 |
| ▸ | CHEK2 | O96017 | 10/20 | 0.55 |
| ▸ | ABL1 | P00519 | 1/20 | 0.53 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.52 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.52 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.50 |
| ▸ | RELA | Q04206 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2316411 | 0.88 | CHEK2 (0.64) | CHEK2KDM4ENPC1USP2ALDH1A1 | |
| SCHEMBL2313477 | 0.87 | SCD (0.59) | SCDCHEK2KDM4ENPC1USP2 | |
| SCHEMBL2802771 | 0.86 | SIRT2 (0.71) | SCDCHEK2SIRT2SIRT1SIRT3 | |
| SCHEMBL2316768 | 0.86 | SCD (0.59) | SCDCHEK2ABL1 | |
| SCHEMBL2315020 | 0.80 | SCD (0.58) | SCDCHEK2ABL1 | |
| SCHEMBL2316764 | 0.80 | CHEK2 (0.77) | SCDCHEK2 | |
| SCHEMBL2317165 | 0.79 | SCD (0.59) | SCDCHEK2ABL1 | |
| SCHEMBL2315595 | 0.78 | SCD (0.79) | SCDCHEK2ABL1 | |
| SCHEMBL2318114 | 0.78 | SCD (0.80) | SCDCHEK2ABL1 | |
| SCHEMBL2317056 | 0.77 | SCD (0.79) | SCDCHEK2ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2183222-B1 | AZOLORAINE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, PHARMACEUTICALS CONTAINING THESE COMPOUNDS, AND THE USE THEREOF | SANOFI SA (FR) | 2011-08-03 | — | — | EP | disclosed |
| EP-2183222-A2 | AZOLORAINE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, PHARMACEUTICALS CONTAINING THESE COMPOUNDS, AND THE USE THEREOF | Sanofi-Aventis (FR) | 2010-05-12 | — | — | EP | disclosed |
| WO-2009024287-A2 | AZOLORAINE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, PHARMACEUTICALS CONTAINING THESE COMPOUNDS, AND THE USE THEREOF | SANOFI-AVENTIS (FR) | 2009-02-26 | — | — | WO | disclosed |