Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 15/20 | 0.43 |
| ▸ | MAOB | P27338 | 6/20 | 0.43 |
| ▸ | MAOA | P21397 | 5/20 | 0.43 |
| ▸ | RCOR1 | Q9UKL0 | 7/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13836698 | 0.81 | KDM1A (0.47) | KDM1AMAOBMAOARCOR1HDAC6 | |
| SCHEMBL2317616 | 0.80 | PSEN1 (0.35) | — | |
| SCHEMBL2364189 | 0.77 | MAOB (0.45) | KDM1AMAOBMAOARCOR1 | |
| SCHEMBL2314346 | 0.77 | MAOB (0.45) | KDM1AMAOBMAOARCOR1 | |
| SCHEMBL2316514 | 0.74 | SLC6A2 (0.38) | MAOA | |
| SCHEMBL2320390 | 0.72 | PSEN1 (0.39) | — | |
| SCHEMBL6917440 | 0.72 | PSEN1 (0.39) | — | |
| SCHEMBL2320306 | 0.72 | PSEN1 (0.39) | — | |
| SCHEMBL14108427 | 0.72 | KDM1A (0.42) | KDM1AMAOBMAOARCOR1 | |
| SCHEMBL10032825 | 0.71 | KDM1A (0.38) | KDM1AMAOBMAOARCOR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011092611-A1 | AMINOCYCLOHEXANES AND AMINOTETRAHYDROPYRANS AND RELATED COMPOUNDS AS GAMMA-SECRETASE MODULATORS | PFIZER INC. (US) | 2011-08-04 | — | — | WO | disclosed |