Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK7 | P49862 | 14/20 | 0.70 |
| ▸ | CTSG | P08311 | 13/20 | 0.70 |
| ▸ | KLK14 | Q9P0G3 | 13/20 | 0.70 |
| ▸ | KLK5 | Q9Y337 | 13/20 | 0.70 |
| ▸ | PRSS1 | P07477 | 4/20 | 0.70 |
| ▸ | CTRC | Q99895 | 5/20 | 0.65 |
| ▸ | C1R | P00736 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29838696 | 1.00 | KLK7 (0.70) | KLK7CTSGKLK14KLK5PRSS1 | |
| SCHEMBL29838634 | 0.92 | KLK7 (0.70) | KLK7CTSGKLK14KLK5PRSS1 | |
| SCHEMBL23159919 | 0.92 | KLK7 (0.70) | KLK7CTSGKLK14KLK5PRSS1 | |
| SCHEMBL23160011 | 0.91 | KLK7 (0.72) | KLK7CTSGKLK14KLK5PRSS1 | |
| SCHEMBL26480329 | 0.85 | KLK7 (0.56) | KLK7CTSGKLK14KLK5PRSS1 | |
| SCHEMBL26481444 | 0.83 | KLK7 (0.56) | KLK7CTSGKLK14KLK5PRSS1 | |
| SCHEMBL26480275 | 0.83 | KLK7 (0.56) | KLK7CTSGKLK14KLK5PRSS1 | |
| SCHEMBL18352896 | 0.83 | KLK7 (1.00) | KLK7CTSGKLK14KLK5PRSS1 | |
| SCHEMBL23159974 | 0.82 | KLK7 (0.72) | KLK7CTSGKLK14KLK5PRSS1 | |
| SCHEMBL29838683 | 0.82 | KLK7 (0.72) | KLK7CTSGKLK14KLK5PRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4037687-B1 | BENZOXAZINONE COMPOUNDS AS KLK5/7 DUAL INHIBITORS | MOLECULAR SKIN THERAPEUTICS INC (US) | 2025-10-29 | — | — | EP | disclosed |
| US-12281123-B2 | Benzoxazinone compounds as KLK5/7 dual inhibitors | MOLECULAR SKIN THERAPEUTICS, INC. (US) | 2025-04-22 | — | — | US | disclosed |
| US-20240067658-A1 | BENZOXAZINONE COMPOUNDS AS KLK5/7 DUAL INHIBITORS | ML Bio Solutions Inc. | 2024-02-29 | — | — | US | disclosed |
| US-20240067658-A1 | BENZOXAZINONE COMPOUNDS AS KLK5/7 DUAL INHIBITORS | ML Bio Solutions Inc. | 2024-02-29 | — | — | US | disclosed |
| US-11643420-B2 | Benzoxazinone compounds as KLK5/7 dual inhibitors | MOLECULAR SKIN THERAPEUTICS, INC. (US) | 2023-05-09 | — | — | US | disclosed |
| US-11643420-B2 | Benzoxazinone compounds as KLK5/7 dual inhibitors | MOLECULAR SKIN THERAPEUTICS, INC. (US) | 2023-05-09 | — | — | US | disclosed |
| WO-2021067335-A1 | BENZOXAZINONE COMPOUNDS AS KLK5/7 DUAL INHIBITORS | MOLECULAR SKIN THERAPEUTICS, INC. (US) | 2021-04-08 | — | — | WO | disclosed |
| US-20210101911-A1 | BENZOXAZINONE COMPOUNDS AS KLK5/7 DUAL INHIBITORS | PHOENIX TISSUE REPAIR, INC. | 2021-04-08 | — | — | US | disclosed |
| US-20210101911-A1 | BENZOXAZINONE COMPOUNDS AS KLK5/7 DUAL INHIBITORS | PHOENIX TISSUE REPAIR, INC. | 2021-04-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12281123-B2 | Benzoxazinone compounds as KLK5/7 dual inhibitors | KLK5, KLK1, KLK2 | KLK7 4/4885CTSG 290/4885KLK14 6/4885 |
| US-20210101911-A1 | BENZOXAZINONE COMPOUNDS AS KLK5/7 DUAL INHIBITORS | KLK5, KLK1, KLK2 | KLK7 4/4885CTSG 290/4885KLK14 6/4885 |
| US-11643420-B2 | Benzoxazinone compounds as KLK5/7 dual inhibitors | KLK5, KLK1, KLK2 | KLK7 4/4885CTSG 290/4885KLK14 6/4885 |
| US-20240067658-A1 | BENZOXAZINONE COMPOUNDS AS KLK5/7 DUAL INHIBITORS | KLK5, KLK1, KLK2 | KLK7 4/4885CTSG 290/4885KLK14 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.