Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK7 | P49862 | 14/20 | 0.70 |
| ▸ | CTSG | P08311 | 13/20 | 0.70 |
| ▸ | KLK14 | Q9P0G3 | 13/20 | 0.70 |
| ▸ | KLK5 | Q9Y337 | 13/20 | 0.70 |
| ▸ | PRSS1 | P07477 | 4/20 | 0.70 |
| ▸ | CTRC | Q99895 | 5/20 | 0.65 |
| ▸ | C1R | P00736 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23159927 | 1.00 | KLK7 (0.70) | KLK7CTSGKLK14KLK5PRSS1 | |
| SCHEMBL29838634 | 0.92 | KLK7 (0.70) | KLK7CTSGKLK14KLK5PRSS1 | |
| SCHEMBL23159919 | 0.92 | KLK7 (0.70) | KLK7CTSGKLK14KLK5PRSS1 | |
| SCHEMBL23160011 | 0.91 | KLK7 (0.72) | KLK7CTSGKLK14KLK5PRSS1 | |
| SCHEMBL26480329 | 0.85 | KLK7 (0.56) | KLK7CTSGKLK14KLK5PRSS1 | |
| SCHEMBL26481444 | 0.83 | KLK7 (0.56) | KLK7CTSGKLK14KLK5PRSS1 | |
| SCHEMBL26480275 | 0.83 | KLK7 (0.56) | KLK7CTSGKLK14KLK5PRSS1 | |
| SCHEMBL18352896 | 0.83 | KLK7 (1.00) | KLK7CTSGKLK14KLK5PRSS1 | |
| SCHEMBL23159974 | 0.82 | KLK7 (0.72) | KLK7CTSGKLK14KLK5PRSS1 | |
| SCHEMBL29838683 | 0.82 | KLK7 (0.72) | KLK7CTSGKLK14KLK5PRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4037687-A1 | BENZOXAZINONE COMPOUNDS AS KLK5/7 DUAL INHIBITORS | Molecular Skin Therapeutics, Inc. (US) | 2022-08-10 | — | — | EP | disclosed |