Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.70 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.70 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.70 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.70 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.70 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.70 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.70 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.70 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.70 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.70 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.70 |
| ▸ | ADAM17 | P78536 | 3/20 | 0.48 |
| ▸ | APAF1 | O14727 | 1/20 | 0.45 |
| ▸ | TNF | P01375 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | GALR3 | O60755 | 2/20 | 0.44 |
| ▸ | NR2F2 | P24468 | 2/20 | 0.44 |
| ▸ | ALPL | P05186 | 2/20 | 0.43 |
| ▸ | ALPG | P10696 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29779589 | 1.00 | HDAC6 (0.70) | HDAC6HDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL29779620 | 0.87 | HDAC1 (0.56) | HDAC6HDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL23167351 | 0.87 | HDAC1 (0.56) | HDAC6HDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL23202499 | 0.85 | HDAC1 (0.52) | HDAC6HDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL23201965 | 0.85 | HDAC6 (0.52) | HDAC6HDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL23201976 | 0.85 | HDAC6 (0.52) | HDAC6HDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL22110373 | 0.83 | HDAC6 (1.00) | HDAC6HDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL23201962 | 0.83 | HDAC1 (0.49) | HDAC6HDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL23167180 | 0.81 | GALR3 (0.56) | HDAC6HDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL12850475 | 0.77 | HDAC1 (1.00) | HDAC6HDAC1HDAC3HDAC4HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230123856-A1 | 5-FLUORONICOTINAMIDE DERIVATIVES AND USES THEREOF | TENAYA THERAPEUTICS, INC. (US) | 2023-04-20 | — | — | US | disclosed |
| US-20230123856-A1 | 5-FLUORONICOTINAMIDE DERIVATIVES AND USES THEREOF | TENAYA THERAPEUTICS, INC. (US) | 2023-04-20 | — | — | US | disclosed |
| EP-4037670-A1 | 5-FLUORONICOTINAMIDE DERIVATIVES AND USES THEREOF | Tenaya Therapeutics, Inc. (US) | 2022-08-10 | — | — | EP | disclosed |
| WO-2021067859-A1 | 5-FLUORONICOTINAMIDE DERIVATIVES AND USES THEREOF | TENAYA THERAPEUTICS, INC. (US) | 2021-04-08 | — | — | WO | disclosed |
| WO-2021067859-A1 | 5-FLUORONICOTINAMIDE DERIVATIVES AND USES THEREOF | TENAYA THERAPEUTICS, INC. (US) | 2021-04-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230123856-A1 | 5-FLUORONICOTINAMIDE DERIVATIVES AND USES THEREOF | SLC28A1, SLC5A1, SLC9A5 | HDAC6 40/4885HDAC1 60/4885HDAC3 367/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.