Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 9/20 | 1.00 |
| ▸ | HDAC1 | Q13547 | 7/20 | 1.00 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 1.00 |
| ▸ | HDAC4 | P56524 | 3/20 | 1.00 |
| ▸ | HDAC2 | Q92769 | 3/20 | 1.00 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 1.00 |
| ▸ | HDAC3 | O15379 | 2/20 | 1.00 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 1.00 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 1.00 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 1.00 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 1.00 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.55 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | GALR3 | O60755 | 1/20 | 0.50 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26079026 | 0.91 | HDAC1 (0.84) | HDAC6HDAC1HDAC8HDAC4HDAC2 | |
| SCHEMBL23951042 | 0.84 | HDAC6 (0.73) | HDAC6HDAC1HDAC8HDAC4HDAC2 | |
| SCHEMBL29779589 | 0.83 | HDAC6 (0.70) | HDAC6HDAC1HDAC8HDAC4HDAC2 | |
| SCHEMBL23167201 | 0.83 | HDAC6 (0.70) | HDAC6HDAC1HDAC8HDAC4HDAC2 | |
| SCHEMBL24754667 | 0.82 | HDAC6 (0.69) | HDAC6HDAC1HDAC8HDAC4HDAC2 | |
| SCHEMBL12850475 | 0.81 | HDAC1 (1.00) | HDAC6HDAC1HDAC8HDAC4HDAC2 | |
| SCHEMBL12938881 | 0.80 | HDAC6 (0.68) | HDAC6HDAC1HDAC8HDAC4HDAC2 | |
| SCHEMBL1160029 | 0.76 | HDAC1 (0.61) | HDAC6HDAC1HDAC8HDAC4HDAC2 | |
| SCHEMBL6170405 | 0.74 | HDAC1 (0.59) | HDAC6HDAC1HDAC8HDAC4HDAC2 | |
| SCHEMBL3671113 | 0.74 | HRH3 (0.68) | HDAC6HDAC1HDAC8HDAC4HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230310400-A9 | SYNTHESIS OF SMALL MOLECULE HISTONE DEACETYLASE 6 DEGRADERS, COMPOUNDS FORMED THEREBY, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2023-10-05 | — | — | US | disclosed |
| US-11059815-B2 | Synthesis of small molecule histone deacetylase 6 degraders, compounds formed thereby, and pharmaceutical compositions containing them | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2021-07-13 | — | — | US | disclosed |
| US-11045458-B2 | Synthesis of small molecule histone deacetylase 6 degraders, compounds formed thereby, and pharmaceutical compositions containing them | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2021-06-29 | — | — | US | disclosed |
| US-20200190079-A1 | SYNTHESIS OF SMALL MOLECULE HISTONE DEACETYLASE 6 DEGRADERS, COMPOUNDS FORMED THEREBY, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | WISCONSIN ALUMNI RESEARCH FOUNDATION | 2020-06-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11045458-B2 | Synthesis of small molecule histone deacetylase 6 degraders, compounds formed thereby, and pharmaceutical compositions containing them | HDAC1, HDAC6, HDAC3 | HDAC6 2/4885HDAC1 1/4885HDAC8 5/4885 |
| US-20230310400-A9 | SYNTHESIS OF SMALL MOLECULE HISTONE DEACETYLASE 6 DEGRADERS, COMPOUNDS FORMED THEREBY, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | HDAC1, HDAC6, HDAC3 | HDAC6 2/4885HDAC1 1/4885HDAC8 5/4885 |
| US-20200190079-A1 | SYNTHESIS OF SMALL MOLECULE HISTONE DEACETYLASE 6 DEGRADERS, COMPOUNDS FORMED THEREBY, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | HDAC1, HDAC6, HDAC3 | HDAC6 2/4885HDAC1 1/4885HDAC8 5/4885 |
| US-11059815-B2 | Synthesis of small molecule histone deacetylase 6 degraders, compounds formed thereby, and pharmaceutical compositions containing them | HDAC1, HDAC6, HDAC3 | HDAC6 2/4885HDAC1 1/4885HDAC8 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.