Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 4/20 | 0.45 |
| ▸ | CA2 | P00918 | 4/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
| ▸ | CA12 | O43570 | 2/20 | 0.44 |
| ▸ | CA7 | P43166 | 2/20 | 0.44 |
| ▸ | CA9 | Q16790 | 2/20 | 0.44 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.44 |
| ▸ | CTSD | P07339 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | CA4 | P22748 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12665837 | 0.85 | KMT2A (0.53) | POLBHTTNPSR1L3MBTL1ALDH1A1 | |
| SCHEMBL8749509 | 0.85 | KMT2A (0.53) | POLBHTTNPSR1L3MBTL1ALDH1A1 | |
| SCHEMBL3645158 | 0.85 | KMT2A (0.53) | POLBHTTNPSR1L3MBTL1ALDH1A1 | |
| SCHEMBL30550438 | 0.85 | KMT2A (0.53) | POLBHTTNPSR1L3MBTL1ALDH1A1 | |
| SCHEMBL7976422 | 0.83 | CA1 (0.47) | POLBHTTNPSR1L3MBTL1ALDH1A1 | |
| SCHEMBL12310919 | 0.81 | ALDH1A1 (0.47) | POLBHTTNPSR1L3MBTL1ALDH1A1 | |
| SCHEMBL31059192 | 0.79 | MEN1 (0.48) | POLBHTTNPSR1L3MBTL1ALDH1A1 | |
| SCHEMBL13656103 | 0.78 | POLB (0.49) | POLBHTTNPSR1L3MBTL1ALDH1A1 | |
| SCHEMBL13170107 | 0.78 | POLB (0.49) | POLBHTTNPSR1L3MBTL1LPAR1 | |
| SCHEMBL15695551 | 0.78 | PTGS1 (0.51) | POLBHTTNPSR1L3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021062246-A1 | CRF RECEPTOR ANTAGONISTS AND METHODS OF USE | NEUROCRINE BIOSCIENCES, INC. (US) | 2021-04-01 | — | — | WO | disclosed |