Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B1 | P14061 | 3/20 | 0.51 |
| ▸ | HSD17B2 | P37059 | 3/20 | 0.51 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.49 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | PARP1 | P09874 | 1/20 | 0.45 |
| ▸ | BCHE | P06276 | 3/20 | 0.43 |
| ▸ | ACHE | P22303 | 2/20 | 0.43 |
| ▸ | ATR | Q13535 | 1/20 | 0.43 |
| ▸ | MET | P08581 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.42 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.42 |
| ▸ | AR | P10275 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2317303 | 0.89 | HSD17B1 (0.51) | HSD17B1HSD17B2PIK3CGPIK3CAPIK3CB | |
| SCHEMBL2317820 | 0.86 | BCHE (0.56) | PIK3CGPARP1BCHEMAPK1AR | |
| SCHEMBL2321967 | 0.79 | HSD17B1 (0.56) | HSD17B1HSD17B2PIK3CGPIK3CAPIK3CB | |
| SCHEMBL3024116 | 0.76 | BCHE (0.67) | HSD17B1HSD17B2BCHEATRMAPK10 | |
| SCHEMBL21638315 | 0.76 | PARP1 (0.38) | PARP1ACHESYK | |
| SCHEMBL29589625 | 0.76 | PARP1 (0.38) | PARP1ACHESYK | |
| SCHEMBL2318698 | 0.76 | NR1H2 (0.59) | HSD17B1HSD17B2PIK3CGPIK3CAPIK3CB | |
| SCHEMBL2320530 | 0.76 | NR1H2 (0.53) | HSD17B1HSD17B2PIK3CGPIK3CAPIK3CB | |
| SCHEMBL11987295 | 0.75 | ATR (0.46) | PARP1ATRRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL3493672 | 0.74 | NR1H2 (0.66) | PARP1SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2352725-A1 | QUINOXALINE-BASED LXR MODULATORS | Wyeth LLC (US) | 2011-08-10 | — | — | EP | disclosed |
| WO-2010054229-A1 | QUINOXALINE-BASED LXR MODULATORS | WYETH LLC (US) | 2010-05-14 | — | — | WO | disclosed |
| US-20100120778-A1 | QUINOXALINE-BASED LXR MODULATORS | WYETH (US) | 2010-05-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100120778-A1 | QUINOXALINE-BASED LXR MODULATORS | NR1H2, NR1H3, NR1H4 | HSD17B1 278/4885HSD17B2 392/4885PIK3CG 4297/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.