Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLP1R | P43220 | 2/20 | 0.41 |
| ▸ | CDK4 | P11802 | 1/20 | 0.38 |
| ▸ | CCND1 | P24385 | 1/20 | 0.38 |
| ▸ | CCND2 | P30279 | 1/20 | 0.38 |
| ▸ | CCND3 | P30281 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.32 |
| ▸ | PIM1 | P11309 | 1/20 | 0.31 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.31 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.31 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23196005 | 0.82 | GLP1R (0.40) | GLP1RCDK4CCND1CCND2CCND3 | |
| SCHEMBL23195819 | 0.82 | GLP1R (0.50) | GLP1RCDK4CCND1CCND2CCND3 | |
| SCHEMBL23195813 | 0.78 | GLP1R (0.38) | GLP1RCDK4CCND1CCND2CCND3 | |
| SCHEMBL23196387 | 0.78 | MAPK8 (0.38) | GLP1RCDK4CCND1CCND2CCND3 | |
| SCHEMBL19145607 | 0.72 | KMT2A (0.33) | GLP1RLMNAMAPTKMT2A | |
| SCHEMBL23196358 | 0.72 | GLP1R (0.33) | GLP1RCDK4CCND1CCND2CCND3 | |
| SCHEMBL270263 | 0.71 | BRD4 (0.52) | AURKAJAK2BRD4FLT3 | |
| SCHEMBL270248 | 0.70 | JAK1 (0.59) | CDK4AURKAKDRAURKBLRRK2 | |
| SCHEMBL23196010 | 0.69 | CDK4 (0.36) | CDK4CCND1CCND2CCND3AURKA | |
| SCHEMBL21681867 | 0.65 | CDK4 (0.40) | CDK4CCND1CCND2CCND3AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4023642-A1 | JNK INHIBITOR, AND PHARMACEUTICAL COMPOSITION AND USE THEREOF | Wuhan LL Science and Technology Development Co., Ltd. (CN) | 2022-07-06 | — | — | EP | disclosed |
| WO-2021063207-A1 | JNK INHIBITOR, AND PHARMACEUTICAL COMPOSITION AND USE THEREOF | 武汉朗来科技发展有限公司 | 2021-04-08 | — | — | WO | disclosed |