Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 1/20 | 0.36 |
| ▸ | CCND1 | P24385 | 1/20 | 0.36 |
| ▸ | CCND2 | P30279 | 1/20 | 0.36 |
| ▸ | CCND3 | P30281 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23195815 | 0.81 | SMN1; SMN2 (0.41) | CDK4CCND1CCND2CCND3SMN1; SMN2 | |
| SCHEMBL13734929 | 0.81 | CDK1 (0.38) | CDK4CCND1CCND2CCND3SMN1; SMN2 | |
| SCHEMBL23196386 | 0.79 | MAPK8 (0.39) | CDK4CCND1CCND2CCND3SMN1; SMN2 | |
| SCHEMBL13733999 | 0.77 | KDM4E (0.37) | CDK4CCND1CCND2CCND3SMN1; SMN2 | |
| SCHEMBL13734259 | 0.74 | MAPK8 (0.48) | KMT2A | |
| SCHEMBL23196359 | 0.70 | — | — | |
| SCHEMBL21711176 | 0.70 | MEN1 (0.34) | KMT2ALMNAALDH1A1 | |
| SCHEMBL23196009 | 0.69 | GLP1R (0.41) | CDK4CCND1CCND2CCND3SMN1; SMN2 | |
| SCHEMBL21681867 | 0.68 | CDK4 (0.40) | CDK4CCND1CCND2CCND3SMN1; SMN2 | |
| SCHEMBL6181403 | 0.67 | RPS6KA5 (0.34) | SMN1; SMN2KMT2AALDH1A1L3MBTL1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4023642-A1 | JNK INHIBITOR, AND PHARMACEUTICAL COMPOSITION AND USE THEREOF | Wuhan LL Science and Technology Development Co., Ltd. (CN) | 2022-07-06 | — | — | EP | disclosed |
| WO-2021063207-A1 | JNK INHIBITOR, AND PHARMACEUTICAL COMPOSITION AND USE THEREOF | 武汉朗来科技发展有限公司 | 2021-04-08 | — | — | WO | disclosed |