Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 4/20 | 0.46 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.45 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.45 |
| ▸ | SYK | P43405 | 6/20 | 0.41 |
| ▸ | JAK3 | P52333 | 3/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.38 |
| ▸ | ACACB | O00763 | 1/20 | 0.38 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.37 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.37 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23195814 | 0.94 | MAPK8 (0.47) | MAPK8MAPK9ADORA3MAPK10SYK | |
| SCHEMBL23196372 | 0.83 | MAPK8 (0.58) | MAPK8MAPK9ADORA3MAPK10SYK | |
| SCHEMBL23196012 | 0.81 | MAPK8 (0.47) | MAPK8MAPK9ADORA3MAPK10SYK | |
| SCHEMBL14320787 | 0.75 | CDK8 (0.47) | — | |
| SCHEMBL1021373 | 0.72 | SYK (0.67) | SYK | |
| SCHEMBL29421239 | 0.71 | RBP4 (0.51) | — | |
| SCHEMBL29421232 | 0.71 | RBP4 (0.51) | — | |
| SCHEMBL14657985 | 0.69 | MAPK8 (0.66) | MAPK8MAPK9ADORA3MAPK10SYK | |
| SCHEMBL14657579 | 0.69 | MAPK8 (0.63) | MAPK8MAPK9ADORA3MAPK10SYK | |
| SCHEMBL14657284 | 0.69 | MAPK8 (0.63) | MAPK8MAPK9ADORA3MAPK10SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4023642-A1 | JNK INHIBITOR, AND PHARMACEUTICAL COMPOSITION AND USE THEREOF | Wuhan LL Science and Technology Development Co., Ltd. (CN) | 2022-07-06 | — | — | EP | disclosed |
| EP-4023642-A1 | JNK INHIBITOR, AND PHARMACEUTICAL COMPOSITION AND USE THEREOF | Wuhan LL Science and Technology Development Co., Ltd. (CN) | 2022-07-06 | — | — | EP | disclosed |
| WO-2021063207-A1 | JNK INHIBITOR, AND PHARMACEUTICAL COMPOSITION AND USE THEREOF | 武汉朗来科技发展有限公司 | 2021-04-08 | — | — | WO | disclosed |