Rifamycin

Rifamycin

SCHEMBL2320

CO[C@H]1/C=C\O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(cc(O)c4c3C2=O)NC(=O)/C(C)=C\C=C/[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

rpoArpoBrpoCrpoZ

The experimentally established mechanism targets of Rifamycin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ABCB11 O95342 5/20 1.00
TBXA2R P21731 3/20 1.00
CHRM1 P11229 3/20 1.00
PTGS1 P23219 3/20 1.00
SLCO2B1 O94956 2/20 1.00
ADRA1A P35348 2/20 1.00
SLCO1A2 P46721 2/20 1.00
SLCO1B3 Q9NPD5 2/20 1.00
SLCO1B1 Q9Y6L6 2/20 1.00
MAPT P10636 4/20 0.70
ABCC4 O15439 4/20 0.70
ABCC2 Q92887 4/20 0.70
GAA P10253 3/20 0.70
MAPK1 P28482 3/20 0.70
ABCC3 O15438 3/20 0.70
NR1I2 O75469 2/20 0.70
ADRB2 P07550 2/20 0.70
ADRB1 P08588 2/20 0.70
ADORA3 P0DMS8 2/20 0.70
ADRA2B P18089 2/20 0.70

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Rifamycin SCHEMBL22389512 1.00 ABCB11 (1.00) ABCB11TBXA2RCHRM1PTGS1SLCO2B1
Rifamycin SCHEMBL31715824 1.00 ABCB11 (1.00) ABCB11TBXA2RCHRM1PTGS1SLCO2B1
Rifamycin SCHEMBL29355202 1.00 ABCB11 (1.00) ABCB11TBXA2RCHRM1PTGS1SLCO2B1
Rifamycin SCHEMBL182452 1.00 ABCB11 (1.00) ABCB11TBXA2RCHRM1PTGS1SLCO2B1
Rifamycin SCHEMBL151824 1.00 ABCB11 (1.00) ABCB11TBXA2RCHRM1PTGS1SLCO2B1
Rifamycin SCHEMBL23370269 1.00 ABCB11 (1.00) ABCB11TBXA2RCHRM1PTGS1SLCO2B1
Rifamycin SCHEMBL29649054 1.00 ABCB11 (1.00) ABCB11TBXA2RCHRM1PTGS1SLCO2B1
Rifamycin SCHEMBL22553368 1.00 ABCB11 (1.00) ABCB11TBXA2RCHRM1PTGS1SLCO2B1
Rifamycin SCHEMBL22389517 0.99 ABCB11 (0.99) ABCB11TBXA2RCHRM1PTGS1SLCO2B1
Rifamycin SCHEMBL29816867 0.99 ABCB11 (0.99) ABCB11TBXA2RCHRM1PTGS1SLCO2B1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 20550 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-122075482-A Use of rifamycin in the treatment of colorectal cancer 2026-05-26 CN claimed
CN-122080018-A Synthetic process for preparing rifampicin by using rifamycin O as starting material 2026-05-26 CN claimed
EP-4057998-B1 PROCESS FOR MANUFACTURING A PHARMACEUTICAL COMPOSITION FOR ORAL INTAKE AND DRUG RELEASE IN THE COLON ETHYPHARM SA (FR) 2026-05-13 EP claimed
US-20260124213-A1 STAPHYLOCOCCUS AUREUS PBP4 INHIBITORS AND METHOD OF USE UNIV ROCHESTER (US) 2026-05-07 US claimed
US-12616708-B2 Methods for treating pulmonary non-tuberculous mycobacterial infections INSMED INCORPORATED (US) 2026-05-05 US claimed
US-20260109712-A1 RIFAMYCINS FOR NONTUBERCULOUS MYCOBACTERIA UNIV MINNESOTA (US) 2026-04-23 US claimed
US-20260108489-A1 TOPICAL NASAL PHARMACEUTICAL COMPOSITION FOR THE TREATMENT AND PROPHYLAXIS OF CHRONIC RHINOSINUSITIS (CRS) VARIZAT EDUARDO ROBERTO (AR) 2026-04-23 US claimed
US-20260076872-A1 POLYMER VIALS WITH SUBSTANTIALLY FLAT BOTTOMS AND INJECTION STRETCH BLOW MOLDING METHODS FOR MAKING THE SAME SIO2 MEDICAL PRODUCTS LLC (US) 2026-03-19 US claimed
EP-4701663-A1 PROLYL HYDROXYLASE DOMAIN-CONTAINING PROTEIN (PHD) INHIBITORS, COMBINATIONS AND USES THEREOF Insilico Medicine IP Limited (HK) 2026-03-04 EP claimed
EP-4698240-A1 ANTIMICROBIAL COMPOSITIONS AND SUTURES COATED THEREWITH Covidien LP (US) 2026-02-25 EP claimed
US-4144234-A Preparation of rifamycin P and Q derivatives GRUPPO LEPETIT S.P.A. (IT) 1979-03-13 US claimed
US-4124585-A Rifamycin compounds ARCHIFAR LABORATORI CHIMICO FARMACOLOGICI S.P.A. (IT) 1978-11-07 US claimed
US-4124586-A Rifamycin compounds ARCHIFAR LABORATORI CHIMICO FARMACOLOGICI S.P.A. (IT) 1978-11-07 US claimed
US-4116957-A ANTIBIOTIC, ANTIBACTERIAL ARCHIFAR INDUSTRIE CHIMICHE DEL TRENTINO S.P.A. (IT) 1978-09-26 US claimed
US-4100276-A BACTERICIDES, MICROBIOCIDES LEO PHARMACEUTICAL PRODUCTS LTD. A/S (DK) 1978-07-11 US claimed
US-4086225-A Rifamycin compounds ARCHIFAR INDUSTRIE CHIMICHE DEL TRENTINO S.P.A. (IT) 1978-04-25 US claimed
US-4060606-A 16-SULFIDES OR SULFOXIDES, STEROIDS, ANTIBACTERIAL LEO PHARMACEUTICAL PRODUCTS LTD. A/S (DK) 1977-11-29 US claimed
US-4024871-A POLYURETHANE ETHICON, INC. (US) 1977-05-24 US claimed
US-4017481-A Rifamycin compounds ARCHIFAR INDUSTRIE CHIMICHE DEL TRENTINO S.P.A. (IT) 1977-04-12 US claimed
US-3987797-A ANTIMICROBIAL SUTURES ETHICON, INC. (US) 1976-10-26 US claimed