Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CTSS | P25774 | 3/20 | 0.41 |
| ▸ | CTSK | P43235 | 2/20 | 0.41 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.40 |
| ▸ | REN | P00797 | 2/20 | 0.40 |
| ▸ | CTSL | P07711 | 1/20 | 0.40 |
| ▸ | CTSB | P07858 | 1/20 | 0.40 |
| ▸ | SDCBP | O00560 | 1/20 | 0.40 |
| ▸ | SDC2 | P34741 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 2/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30882362 | 1.00 | AAK1 (0.43) | AAK1ATMKMT2ACTSSCTSK | |
| SCHEMBL23201197 | 1.00 | AAK1 (0.43) | AAK1ATMKMT2ACTSSCTSK | |
| SCHEMBL5389519 | 0.87 | EPHX2 (0.44) | AAK1ATMCTSSCTSKCXCR3 | |
| SCHEMBL4816579 | 0.87 | EPHX2 (0.44) | AAK1ATMCTSSCTSKCXCR3 | |
| SCHEMBL29911641 | 0.87 | EPHX2 (0.44) | AAK1ATMCTSSCTSKCXCR3 | |
| SCHEMBL1598690 | 0.87 | EPHX2 (0.44) | AAK1ATMCTSSCTSKCXCR3 | |
| SCHEMBL30387713 | 0.86 | SYK (0.48) | CTSSCTSLPPARA | |
| SCHEMBL25054153 | 0.86 | SYK (0.48) | CTSSCTSLPPARA | |
| SCHEMBL10118949 | 0.81 | SDCBP (0.42) | KMT2ASDCBPSDC2 | |
| SCHEMBL6683090 | 0.80 | PSEN1 (0.47) | AAK1CTSSCTSKRENCTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117964684-A | MASP-2 inhibitors and methods of use | 奥默罗斯公司 | 2024-05-03 | — | — | CN | disclosed |
| CN-117964683-A | MASP-2 inhibitors and methods of use | 奥默罗斯公司 | 2024-05-03 | — | — | CN | disclosed |
| CN-112867706-A | MASP-2 inhibitors and methods of use | 奥默罗斯公司 | 2021-05-28 | — | — | CN | disclosed |
| EP-3802489-A2 | MASP-2 INHIBITORS AND METHODS OF USE | Omeros Corporation (US) | 2021-04-14 | — | — | EP | disclosed |