Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 7/20 | 0.47 |
| ▸ | IMPDH2 | P12268 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | TTK | P33981 | 1/20 | 0.43 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.42 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.42 |
| ▸ | CCNC | P24863 | 1/20 | 0.42 |
| ▸ | CDK8 | P49336 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ITK | Q08881 | 1/20 | 0.41 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.41 |
| ▸ | DHODH | Q02127 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30882649 | 1.00 | PARP1 (0.47) | PARP1IMPDH2KDM4ECA12CA9 | |
| SCHEMBL2115397 | 0.86 | XDH (0.47) | PARP1IMPDH2KDM4ECA12CA9 | |
| SCHEMBL6768125 | 0.83 | SMYD3 (0.55) | KDM4EMAPKAPK2ALDH1A1GAASMYD3 | |
| SCHEMBL938618 | 0.81 | PARP1 (0.69) | PARP1KDM4ECSNK2A1ALDH1A1HPGD | |
| SCHEMBL31042188 | 0.81 | PARP1 (0.69) | PARP1KDM4ECSNK2A1ALDH1A1HPGD | |
| SCHEMBL1084591 | 0.80 | PARP1 (0.66) | PARP1KDM4ECA12CA9CSNK2A1 | |
| SCHEMBL3260502 | 0.79 | PARP1 (0.60) | PARP1KDM4ECA12CA9CSNK2A1 | |
| SCHEMBL29935457 | 0.79 | PARP1 (0.60) | PARP1KDM4ECA12CA9CSNK2A1 | |
| SCHEMBL13648691 | 0.77 | PARP1 (0.71) | PARP1IMPDH2CSNK2A1CSNK2A2CSNK2B | |
| SCHEMBL14016637 | 0.77 | POLB (0.57) | KDM4EMAPKAPK2SMN1; SMN2SMYD3HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3802489-A2 | MASP-2 INHIBITORS AND METHODS OF USE | Omeros Corporation (US) | 2021-04-14 | — | — | EP | disclosed |