Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDCD1 | Q15116 | 18/20 | 0.40 |
| ▸ | CD274 | Q9NZQ7 | 18/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23198481 | 0.93 | PDCD1 (0.47) | PDCD1CD274 | |
| SCHEMBL23201522 | 0.89 | PRMT5 (0.45) | PDCD1CD274 | |
| SCHEMBL23201345 | 0.88 | PDCD1 (0.47) | PDCD1CD274 | |
| SCHEMBL23202675 | 0.83 | PDCD1 (0.41) | PDCD1CD274 | |
| SCHEMBL23199854 | 0.81 | PDCD1 (0.39) | PDCD1CD274 | |
| SCHEMBL23198918 | 0.80 | GRM2 (0.34) | MAPT | |
| SCHEMBL23198483 | 0.79 | GRM2 (0.35) | MAPT | |
| SCHEMBL24722394 | 0.79 | PDCD1 (0.37) | PDCD1CD274 | |
| SCHEMBL23202652 | 0.79 | PARP1 (0.43) | — | |
| SCHEMBL23198440 | 0.77 | GRM2 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4043461-A1 | COMPOUND AS SMALL MOLECULE INHIBITOR PD-1/PD-L1 AND APPLICATION THEREOF | Medshine Discovery Inc. (CN) | 2022-08-17 | — | — | EP | disclosed |
| WO-2021063404-A1 | COMPOUND AS SMALL MOLECULE INHIBITOR PD-1/PD-L1 AND APPLICATION THEREOF | 南京明德新药研发有限公司 | 2021-04-08 | — | — | WO | disclosed |