Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | PKM | P14618 | 2/20 | 0.52 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | HTT | P42858 | 4/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | KDM6B | O15054 | 1/20 | 0.43 |
| ▸ | KDM4A | O75164 | 1/20 | 0.43 |
| ▸ | KDM5C | P41229 | 1/20 | 0.43 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.43 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.43 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CCR1 | P32246 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31096524 | 1.00 | KDM4E (0.52) | KDM4EMEN1KMT2AALDH1A1PKM | |
| SCHEMBL23202504 | 0.88 | KDM4E (0.47) | KDM4EMEN1KMT2AALDH1A1PKM | |
| SCHEMBL31096548 | 0.88 | KDM4E (0.47) | KDM4EMEN1KMT2AALDH1A1PKM | |
| SCHEMBL31096525 | 0.85 | KDM4E (0.69) | KDM4EMEN1KMT2AALDH1A1PKM | |
| SCHEMBL23202557 | 0.85 | KDM4E (0.69) | KDM4EMEN1KMT2AALDH1A1PKM | |
| SCHEMBL23479904 | 0.85 | HTT (0.47) | KDM4EMEN1KMT2AALDH1A1PKM | |
| SCHEMBL31096541 | 0.85 | KDM4E (0.53) | KDM4EMEN1KMT2AALDH1A1PKM | |
| SCHEMBL23202481 | 0.85 | HTT (0.53) | KDM4EMEN1KMT2AALDH1A1PKM | |
| SCHEMBL23202617 | 0.85 | KDM4E (0.53) | KDM4EMEN1KMT2AALDH1A1PKM | |
| SCHEMBL23202494 | 0.84 | KDM4E (0.57) | KDM4EMEN1KMT2AALDH1A1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4685140-A1 | EAAT2 ACTIVATORS AND METHODS OF USING THEREOF | Ohio State Innovation Foundation (US) | 2026-01-28 | — | — | EP | disclosed |
| EP-3801528-B1 | EAAT2 ACTIVATORS AND METHODS OF USING THEREOF | OHIO STATE INNOVATION FOUNDATION (US) | 2025-08-06 | — | — | EP | disclosed |
| US-12286420-B2 | EAAT2 activators and methods of using thereof | OHIO STATE INNOVATION FOUNDATION (US) | 2025-04-29 | — | — | US | disclosed |
| US-20240208936-A1 | EAAT2 ACTIVATORS AND METHODS OF USING THEREOF | OHIO STATE INNOVATION FOUNDATION (US) | 2024-06-27 | — | — | US | disclosed |
| US-11702403-B2 | EAAT2 activators and methods of using thereof | OHIO STATE INNOVATION FOUNDATION (US) | 2023-07-18 | — | — | US | disclosed |
| US-11702403-B2 | EAAT2 activators and methods of using thereof | OHIO STATE INNOVATION FOUNDATION (US) | 2023-07-18 | — | — | US | disclosed |
| US-11702403-B2 | EAAT2 activators and methods of using thereof | OHIO STATE INNOVATION FOUNDATION (US) | 2023-07-18 | — | — | US | disclosed |
| US-20230138663-A1 | EAAT2 ACTIVATORS AND METHODS OF USING THEREOF | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. | 2023-05-04 | — | — | US | disclosed |
| US-20230138663-A1 | EAAT2 ACTIVATORS AND METHODS OF USING THEREOF | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. | 2023-05-04 | — | — | US | disclosed |
| US-20230138663-A1 | EAAT2 ACTIVATORS AND METHODS OF USING THEREOF | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. | 2023-05-04 | — | — | US | disclosed |
| US-20210171497-A1 | EAAT2 ACTIVATORS AND METHODS OF USING THEREOF | OHIO STATE INNOVATION FOUNDATION | 2021-06-10 | — | — | US | disclosed |
| US-20210171497-A1 | EAAT2 ACTIVATORS AND METHODS OF USING THEREOF | OHIO STATE INNOVATION FOUNDATION | 2021-06-10 | — | — | US | disclosed |
| EP-3801528-A1 | EAAT2 ACTIVATORS AND METHODS OF USING THEREOF | Ohio State Innovation Foundation (US) | 2021-04-14 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11702403-B2 | EAAT2 activators and methods of using thereof | SLC1A2, SLC1A1, SLC18A2 | KDM4E 3928/4885MEN1 4789/4885KMT2A 1319/4885 |
| US-12286420-B2 | EAAT2 activators and methods of using thereof | SLC1A2, SLC1A1, SLC18A2 | KDM4E 3928/4885MEN1 4789/4885KMT2A 1319/4885 |
| US-20230138663-A1 | EAAT2 ACTIVATORS AND METHODS OF USING THEREOF | SLC1A2, SLC1A1, SLC18A2 | KDM4E 3928/4885MEN1 4789/4885KMT2A 1319/4885 |
| US-20240208936-A1 | EAAT2 ACTIVATORS AND METHODS OF USING THEREOF | SLC1A2, SLC1A1, SLC18A2 | KDM4E 3928/4885MEN1 4789/4885KMT2A 1319/4885 |
| US-20210171497-A1 | EAAT2 ACTIVATORS AND METHODS OF USING THEREOF | SLC1A2, SLC1A1, SLC18A2 | KDM4E 3928/4885MEN1 4789/4885KMT2A 1319/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.