Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.36 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.36 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.36 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.36 |
| ▸ | NCF1 | P14598 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.32 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.32 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23204650 | 1.00 | CACNA2D1 (0.36) | CACNA2D1CACNA1BCACNB1CACNA1CNCF1 | |
| SCHEMBL24204676 | 0.88 | KDM4E (0.33) | CACNA2D1CACNA1BCACNB1CACNA1CNCF1 | |
| SCHEMBL22906588 | 0.87 | NCF1 (0.39) | CACNA2D1CACNA1BCACNB1CACNA1CNCF1 | |
| SCHEMBL23204653 | 0.87 | NCF1 (0.39) | CACNA2D1CACNA1BCACNB1CACNA1CNCF1 | |
| SCHEMBL24717541 | 0.83 | CACNA2D1 (0.35) | CACNA2D1CACNA1BCACNB1ACHECHRM5 | |
| SCHEMBL25609366 | 0.82 | NCF1 (0.32) | NCF1CHRM5ADRA2C | |
| SCHEMBL23205152 | 0.82 | NCF1 (0.32) | NCF1CHRM5ADRA2C | |
| SCHEMBL24204800 | 0.81 | NCF1 (0.43) | CACNA2D1CACNA1BCACNB1CACNA1CNCF1 | |
| SCHEMBL25607712 | 0.80 | CACNA2D1 (0.32) | CACNA2D1CACNA1BCACNB1CACNA1CNCF1 | |
| SCHEMBL23205549 | 0.80 | NCF1 (0.42) | CACNA2D1CACNA1BCACNB1CACNA1CNCF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021067606-A1 | BRM TARGETING COMPOUNDS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. (US) | 2021-04-08 | — | — | WO | disclosed |