Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.38 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.38 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.34 |
| ▸ | LOX | P28300 | 1/20 | 0.34 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.34 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23205104 | 1.00 | TLR9 (0.38) | TLR9TLR8TLR7PIK3CDKCNH2 | |
| SCHEMBL26157155 | 0.91 | TLR9 (0.41) | TLR9TLR8TLR7PIK3CDKCNH2 | |
| SCHEMBL26157172 | 0.88 | TLR9 (0.35) | TLR9TLR8TLR7HCRTR1HCRTR2 | |
| SCHEMBL26157171 | 0.88 | TLR9 (0.35) | TLR9TLR8TLR7HCRTR1HCRTR2 | |
| SCHEMBL26157127 | 0.84 | HRH3 (0.39) | HCRTR1HCRTR2LOXLOXL2 | |
| SCHEMBL26157126 | 0.84 | HRH3 (0.39) | HCRTR1HCRTR2LOXLOXL2 | |
| SCHEMBL26157284 | 0.84 | HCRTR1 (0.39) | TLR9TLR8TLR7KCNH2HCRTR1 | |
| SCHEMBL24838010 | 0.81 | TLR9 (0.36) | TLR9TLR8TLR7HCRTR1HCRTR2 | |
| SCHEMBL26157195 | 0.81 | HCRTR1 (0.38) | PIK3CDHCRTR1HCRTR2LRRK2LOX | |
| SCHEMBL427767 | 0.80 | LRRK2 (0.48) | PIK3CDHCRTR1HCRTR2LRRK2LOX |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023096987-A1 | BRM TARGETING COMPOUNDS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. (US) | 2023-06-01 | — | — | WO | disclosed |
| WO-2021067606-A1 | BRM TARGETING COMPOUNDS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. (US) | 2021-04-08 | — | — | WO | disclosed |