SCHEMBL2321093

SCHEMBL2321093

OC1CC2NC=CC=C2S1

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17425936 0.56
SCHEMBL13156878 0.54
SCHEMBL998763 0.52
SCHEMBL9131788 0.51
SCHEMBL7106317 0.51
SCHEMBL10623294 0.46
SCHEMBL17451017 0.45
SCHEMBL13759762 0.45
SCHEMBL17513339 0.41
SCHEMBL24111513 0.40

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 85 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114286823-B Optically active 2-hydroxy tetrahydrothiophene pyridine derivative and preparation method and application thereof 天地恒一制药股份有限公司 2023-11-28 CN claimed
CN-116744921-A Optically active 2-hydroxy tetrahydrothiophene pyridine derivative and preparation method and application thereof 天地恒一制药股份有限公司 2023-09-12 CN claimed
WO-2023134682-A1 OPTICALLY ACTIVE 2-HYDROXYTETRAHYDROTHIENOPYRIDINE DERIVATIVE, AND PREPARATION METHOD THEREFOR AND USE THEREOF 天地恒一制药股份有限公司 2023-07-20 WO claimed
CN-114286823-A Optically active 2-hydroxy tetrahydrothienopyridine derivative and preparation method and application thereof 天地恒一制药股份有限公司 2022-04-05 CN claimed
WO-2022028347-A1 OPTICALLY ACTIVE 2-HYDROXYLTETRAHYDROTHIENOPYRIDINE DERIVATIVE, AND PREPARATION METHOD THEREFOR AND USE THEREOF 天地恒一制药股份有限公司 2022-02-10 WO claimed
EP-3290423-B1 OPTICALLY ACTIVE 2-HYDROXY TETRAHYDROTHIENOPYRIDINE DERIVATIVES, PREPARATION METHOD AND USE IN MANUFACTURE OF MEDICAMENT THEREOF JIANGSU VCARE PHARMATECH CO LTD (CN) 2021-07-21 EP claimed
EP-3290423-A1 OPTICALLY ACTIVE 2-HYDROXY TETRAHYDROTHIENOPYRIDINE DERIVATIVES, PREPARATION METHOD AND USE IN MANUFACTURE OF MEDICAMENT THEREOF Jiangsu Vcare Pharmatech Co., Ltd (CN) 2018-03-07 EP claimed
EP-2532668-B1 OPTICALLY ACTIVE 2-HYDROXY TETRAHYDROTHIENOPYRIDINE DERIVATIVES, PREPARATION METHOD AND USE IN MANUFACTURE OF MEDICAMENT THEREOF JIANGSU VCARE PHARMATECH CO LTD (CN) 2017-05-24 EP claimed
US-20170121341-A1 OPTICALLY ACTIVE 2-HYDROXY TETRAHYDROTHIENOPYRIDINE DERIVATIVES, PREPARATION METHOD AND USE IN MANUFACTURE OF MEDICAMENT THEREOF JIANGSU VCARE PHARMATECH CO., LTD. (CN) 2017-05-04 US claimed
CN-103665042-B Optically active 2-hydroxy tetrahydro thienopyridine derivative and its production and use BEIJING PRELUDE PHARM TECHNOLOGY CO., LTD. (CN) 2016-03-16 CN claimed
US-8772489-B2 Optically active 2-hydroxy tetrahydrothienopyridine derivatives, preparation method and use in manufacture of medicament thereof Jiangsu Vcare PharmaTech Co. Ltd. (CN) 2014-07-08 US claimed
CN-103665042-A Optically active 2-hydroxyltetrahydrothienopyridine derivative as well as preparation method and use thereof BEIJING PRELUDE PHARMACEUTICAL TECHNOLOGY CO LTD 2014-03-26 CN claimed
CN-102863457-B Optically-active 2- hydroxyltetrathienopyridine derivative, preparation method thereof and application of optically-active 2- hydroxyltetrathienopyridine derivative to pharmacy JIANGSU VCARE PHARMATECH CO LTD 2013-10-09 CN claimed
US-20130165476-A1 OPTICALLY ACTIVE 2-HYDROXY TETRAHYDROTHIENOPYRIDINE DERIVATIVES, PREPARATION METHOD AND USE IN MANUFACTURE OF MEDICAMENT THEREOF JIANGSU VCARE PHARMATECH CO., LTD. (CN) 2013-06-27 US claimed
CN-102863457-A Optically-active 2- hydroxyltetrathienopyridine derivative, preparation method thereof and application of optically-active 2- hydroxyltetrathienopyridine derivative to pharmacy JIANGSU VCARE PHARMATECH CO LTD 2013-01-09 CN claimed
CN-102120744-B Optically active 2-hydroxy tetrahydrothienopyridine derivative, preparation method and application thereof in pharmacy JIANGSU VCARE PHARMATECH CO LTD 2013-01-09 CN claimed
EP-2532668-A1 OPTICALLY ACTIVE 2-HYDROXY TETRAHYDROTHIENOPYRIDINE DERIVATIVES, PREPARATION METHOD AND USE IN MANUFACTURE OF MEDICAMENT THEREOF Jiangsu Vcare Pharmatech Co., Ltd (CN) 2012-12-12 EP claimed
CN-102199163-A 2-hydroxy tetrahydrothiophene derivative, preparation method thereof and application thereof in pharmacy UNIV CHINA PHARMA 2011-09-28 CN claimed
CN-102120744-A Optically active 2-hydroxy tetrahydrothienopyridine derivative, preparation method and application thereof in pharmacy JIANGSU VCARE PHARMATECH CO LTD 2011-07-13 CN claimed
CN-114286823-B Optically active 2-hydroxy tetrahydrothiophene pyridine derivative and preparation method and application thereof 天地恒一制药股份有限公司 2023-11-28 CN disclosed
CN-116744921-A Optically active 2-hydroxy tetrahydrothiophene pyridine derivative and preparation method and application thereof 天地恒一制药股份有限公司 2023-09-12 CN disclosed
WO-2023134682-A1 OPTICALLY ACTIVE 2-HYDROXYTETRAHYDROTHIENOPYRIDINE DERIVATIVE, AND PREPARATION METHOD THEREFOR AND USE THEREOF 天地恒一制药股份有限公司 2023-07-20 WO disclosed
WO-2023134682-A1 OPTICALLY ACTIVE 2-HYDROXYTETRAHYDROTHIENOPYRIDINE DERIVATIVE, AND PREPARATION METHOD THEREFOR AND USE THEREOF 天地恒一制药股份有限公司 2023-07-20 WO disclosed
WO-2023134682-A1 OPTICALLY ACTIVE 2-HYDROXYTETRAHYDROTHIENOPYRIDINE DERIVATIVE, AND PREPARATION METHOD THEREFOR AND USE THEREOF 天地恒一制药股份有限公司 2023-07-20 WO disclosed
CN-114286823-A Optically active 2-hydroxy tetrahydrothienopyridine derivative and preparation method and application thereof 天地恒一制药股份有限公司 2022-04-05 CN disclosed
CN-114286823-A Optically active 2-hydroxy tetrahydrothienopyridine derivative and preparation method and application thereof 天地恒一制药股份有限公司 2022-04-05 CN disclosed
CN-114286823-A Optically active 2-hydroxy tetrahydrothienopyridine derivative and preparation method and application thereof 天地恒一制药股份有限公司 2022-04-05 CN disclosed
WO-2022028347-A1 OPTICALLY ACTIVE 2-HYDROXYLTETRAHYDROTHIENOPYRIDINE DERIVATIVE, AND PREPARATION METHOD THEREFOR AND USE THEREOF 天地恒一制药股份有限公司 2022-02-10 WO disclosed
WO-2022028347-A1 OPTICALLY ACTIVE 2-HYDROXYLTETRAHYDROTHIENOPYRIDINE DERIVATIVE, AND PREPARATION METHOD THEREFOR AND USE THEREOF 天地恒一制药股份有限公司 2022-02-10 WO disclosed
WO-2022028347-A1 OPTICALLY ACTIVE 2-HYDROXYLTETRAHYDROTHIENOPYRIDINE DERIVATIVE, AND PREPARATION METHOD THEREFOR AND USE THEREOF 天地恒一制药股份有限公司 2022-02-10 WO disclosed
EP-3290423-B1 OPTICALLY ACTIVE 2-HYDROXY TETRAHYDROTHIENOPYRIDINE DERIVATIVES, PREPARATION METHOD AND USE IN MANUFACTURE OF MEDICAMENT THEREOF JIANGSU VCARE PHARMATECH CO LTD (CN) 2021-07-21 EP disclosed
EP-2613783-B1 METHODS FOR THE TREATMENT OR PROPHYLAXIS OF THROMBOSIS OR EMBOLISM IPCA LABORATORIES LTD (IN) 2019-06-12 EP disclosed
EP-2943482-B1 MIXED DISULFIDE CONJUGATES OF THIENOPYRIDINE COMPOUNDS AND USES THEREOF UNIV MICHIGAN REGENTS (US) 2019-03-13 EP disclosed
US-20190055260-A1 OPTICALLY ACTIVE 2-HYDROXY TETRAHYDROTHIENOPYRIDINE DERIVATIVES, PREPARATION METHOD AND USE IN MANUFACTURE OF MEDICAMENT THEREOF JIANGSU VCARE PHARMATECH CO., LTD. (CN) 2019-02-21 US disclosed
US-20190055260-A1 OPTICALLY ACTIVE 2-HYDROXY TETRAHYDROTHIENOPYRIDINE DERIVATIVES, PREPARATION METHOD AND USE IN MANUFACTURE OF MEDICAMENT THEREOF JIANGSU VCARE PHARMATECH CO., LTD. (CN) 2019-02-21 US disclosed
US-10000506-B2 Optically active 2-hydroxy tetrahydrothienopyridine derivatives, preparation method and use in manufacture of medicament thereof JIANGSU VCARE PHARMATECH CO., LTD. (CN) 2018-06-19 US disclosed
US-10000506-B2 Optically active 2-hydroxy tetrahydrothienopyridine derivatives, preparation method and use in manufacture of medicament thereof JIANGSU VCARE PHARMATECH CO., LTD. (CN) 2018-06-19 US disclosed
US-10000506-B2 Optically active 2-hydroxy tetrahydrothienopyridine derivatives, preparation method and use in manufacture of medicament thereof JIANGSU VCARE PHARMATECH CO., LTD. (CN) 2018-06-19 US disclosed
CN-104418891-B The preparation of water-soluble 2 hydroxy tetrahydro thienopyridine derivatives and its medical usage 江苏威凯尔医药科技有限公司 2018-04-06 CN disclosed
CN-104418891-B The preparation of water-soluble 2 hydroxy tetrahydro thienopyridine derivatives and its medical usage 江苏威凯尔医药科技有限公司 2018-04-06 CN disclosed
CN-104418891-B The preparation of water-soluble 2 hydroxy tetrahydro thienopyridine derivatives and its medical usage 江苏威凯尔医药科技有限公司 2018-04-06 CN disclosed
EP-3290423-A1 OPTICALLY ACTIVE 2-HYDROXY TETRAHYDROTHIENOPYRIDINE DERIVATIVES, PREPARATION METHOD AND USE IN MANUFACTURE OF MEDICAMENT THEREOF Jiangsu Vcare Pharmatech Co., Ltd (CN) 2018-03-07 EP disclosed
CN-103772270-B Metabolite markers, the preparation method and the usage of the hydroxy tetrahydro thienopyridine derivative of optical activity 2 江苏威凯尔医药科技有限公司 2017-12-26 CN disclosed
CN-103772270-B Metabolite markers, the preparation method and the usage of the hydroxy tetrahydro thienopyridine derivative of optical activity 2 江苏威凯尔医药科技有限公司 2017-12-26 CN disclosed
CN-103772270-B Metabolite markers, the preparation method and the usage of the hydroxy tetrahydro thienopyridine derivative of optical activity 2 江苏威凯尔医药科技有限公司 2017-12-26 CN disclosed
EP-2532668-B1 OPTICALLY ACTIVE 2-HYDROXY TETRAHYDROTHIENOPYRIDINE DERIVATIVES, PREPARATION METHOD AND USE IN MANUFACTURE OF MEDICAMENT THEREOF JIANGSU VCARE PHARMATECH CO LTD (CN) 2017-05-24 EP disclosed
US-20170121341-A1 OPTICALLY ACTIVE 2-HYDROXY TETRAHYDROTHIENOPYRIDINE DERIVATIVES, PREPARATION METHOD AND USE IN MANUFACTURE OF MEDICAMENT THEREOF JIANGSU VCARE PHARMATECH CO., LTD. (CN) 2017-05-04 US disclosed
US-20170121341-A1 OPTICALLY ACTIVE 2-HYDROXY TETRAHYDROTHIENOPYRIDINE DERIVATIVES, PREPARATION METHOD AND USE IN MANUFACTURE OF MEDICAMENT THEREOF JIANGSU VCARE PHARMATECH CO., LTD. (CN) 2017-05-04 US disclosed
CN-103665042-B Optically active 2-hydroxy tetrahydro thienopyridine derivative and its production and use BEIJING PRELUDE PHARM TECHNOLOGY CO., LTD. (CN) 2016-03-16 CN disclosed
CN-103665042-B Optically active 2-hydroxy tetrahydro thienopyridine derivative and its production and use BEIJING PRELUDE PHARM TECHNOLOGY CO., LTD. (CN) 2016-03-16 CN disclosed
CN-103665042-B Optically active 2-hydroxy tetrahydro thienopyridine derivative and its production and use BEIJING PRELUDE PHARM TECHNOLOGY CO., LTD. (CN) 2016-03-16 CN disclosed
CN-103554132-B Deuterated derivative of tetrahydrothieno pyridines and preparation method thereof and pharmaceutical use LI JINING (CN) 2016-01-27 CN disclosed
CN-104418891-A Preparation method and medical application of water-soluble 2-hydroxyl tetrahydrothienopyridine derivatives JIANGSU VCARE PHARMATECH CO LTD 2015-03-18 CN disclosed
CN-104418891-A Preparation method and medical application of water-soluble 2-hydroxyl tetrahydrothienopyridine derivatives JIANGSU VCARE PHARMATECH CO LTD 2015-03-18 CN disclosed
CN-104418891-A Preparation method and medical application of water-soluble 2-hydroxyl tetrahydrothienopyridine derivatives JIANGSU VCARE PHARMATECH CO LTD 2015-03-18 CN disclosed
US-20150011583-A1 OPTICALLY ACTIVE 2-HYDROXY TETRAHYDROTHIENOPYRIDINE DERIVATIVES, PREPARATION METHOD AND USE IN MANUFACTURE OF MEDICAMENT THEREOF JIANGSU VCARE PHARMATECH CO., LTD. (CN) 2015-01-08 US disclosed
US-20150011583-A1 OPTICALLY ACTIVE 2-HYDROXY TETRAHYDROTHIENOPYRIDINE DERIVATIVES, PREPARATION METHOD AND USE IN MANUFACTURE OF MEDICAMENT THEREOF JIANGSU VCARE PHARMATECH CO., LTD. (CN) 2015-01-08 US disclosed
US-8772489-B2 Optically active 2-hydroxy tetrahydrothienopyridine derivatives, preparation method and use in manufacture of medicament thereof Jiangsu Vcare PharmaTech Co. Ltd. (CN) 2014-07-08 US disclosed
US-8772489-B2 Optically active 2-hydroxy tetrahydrothienopyridine derivatives, preparation method and use in manufacture of medicament thereof Jiangsu Vcare PharmaTech Co. Ltd. (CN) 2014-07-08 US disclosed
US-8772489-B2 Optically active 2-hydroxy tetrahydrothienopyridine derivatives, preparation method and use in manufacture of medicament thereof Jiangsu Vcare PharmaTech Co. Ltd. (CN) 2014-07-08 US disclosed
CN-103772270-A Metabolin marker of 2-hydroxyl radical tetrahydro-thiophene pyridine derivative with optical activity as well as preparation and application thereof JIANGSU VCARE PHARMATECH CO LTD 2014-05-07 CN disclosed
WO-2014043895-A1 2-HYDROXYL TETRAHYDRO THIENOPYRIDINE DERIVATIVE WITH OPTICAL ACTIVITY AND PREPARATION METHOD AND USE THEREOF 北京普禄德医药科技有限公司 (CN) 2014-03-27 WO disclosed
CN-103665042-A Optically active 2-hydroxyltetrahydrothienopyridine derivative as well as preparation method and use thereof BEIJING PRELUDE PHARMACEUTICAL TECHNOLOGY CO LTD 2014-03-26 CN disclosed
CN-103665042-A Optically active 2-hydroxyltetrahydrothienopyridine derivative as well as preparation method and use thereof BEIJING PRELUDE PHARMACEUTICAL TECHNOLOGY CO LTD 2014-03-26 CN disclosed
CN-103665042-A Optically active 2-hydroxyltetrahydrothienopyridine derivative as well as preparation method and use thereof BEIJING PRELUDE PHARMACEUTICAL TECHNOLOGY CO LTD 2014-03-26 CN disclosed
CN-103554132-A Tetrahydrothieno-[2,3-c]pyridine deuterated derivatives and preparation method and medicament applications thereof LI JINING 2014-02-05 CN disclosed
CN-102863457-B Optically-active 2- hydroxyltetrathienopyridine derivative, preparation method thereof and application of optically-active 2- hydroxyltetrathienopyridine derivative to pharmacy JIANGSU VCARE PHARMATECH CO LTD 2013-10-09 CN disclosed
US-20130165476-A1 OPTICALLY ACTIVE 2-HYDROXY TETRAHYDROTHIENOPYRIDINE DERIVATIVES, PREPARATION METHOD AND USE IN MANUFACTURE OF MEDICAMENT THEREOF JIANGSU VCARE PHARMATECH CO., LTD. (CN) 2013-06-27 US disclosed
US-20130165476-A1 OPTICALLY ACTIVE 2-HYDROXY TETRAHYDROTHIENOPYRIDINE DERIVATIVES, PREPARATION METHOD AND USE IN MANUFACTURE OF MEDICAMENT THEREOF JIANGSU VCARE PHARMATECH CO., LTD. (CN) 2013-06-27 US disclosed
CN-102120744-B Optically active 2-hydroxy tetrahydrothienopyridine derivative, preparation method and application thereof in pharmacy JIANGSU VCARE PHARMATECH CO LTD 2013-01-09 CN disclosed
CN-102120744-B Optically active 2-hydroxy tetrahydrothienopyridine derivative, preparation method and application thereof in pharmacy JIANGSU VCARE PHARMATECH CO LTD 2013-01-09 CN disclosed
CN-102863457-A Optically-active 2- hydroxyltetrathienopyridine derivative, preparation method thereof and application of optically-active 2- hydroxyltetrathienopyridine derivative to pharmacy JIANGSU VCARE PHARMATECH CO LTD 2013-01-09 CN disclosed
CN-102120744-B Optically active 2-hydroxy tetrahydrothienopyridine derivative, preparation method and application thereof in pharmacy JIANGSU VCARE PHARMATECH CO LTD 2013-01-09 CN disclosed
CN-102838617-A Polymorph and pharmaceutical composition of (S)-2-(2- nicotinoyloxyjatropha-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-yl)-2-(2-chlorphenyl)-methyl acetate JIANGSU VCARE PHARMATECH CO LTD 2012-12-26 CN disclosed
CN-102827184-A Polymorph of 2-hydroxy tetrahydrothienopyridine derivatives and pharmaceutical composition JIANGSU VCARE PHARMATECH CO LTD 2012-12-19 CN disclosed
CN-102827184-A Polymorph of 2-hydroxy tetrahydrothienopyridine derivatives and pharmaceutical composition JIANGSU VCARE PHARMATECH CO LTD 2012-12-19 CN disclosed
EP-2532668-A1 OPTICALLY ACTIVE 2-HYDROXY TETRAHYDROTHIENOPYRIDINE DERIVATIVES, PREPARATION METHOD AND USE IN MANUFACTURE OF MEDICAMENT THEREOF Jiangsu Vcare Pharmatech Co., Ltd (CN) 2012-12-12 EP disclosed
EP-2532668-A1 OPTICALLY ACTIVE 2-HYDROXY TETRAHYDROTHIENOPYRIDINE DERIVATIVES, PREPARATION METHOD AND USE IN MANUFACTURE OF MEDICAMENT THEREOF Jiangsu Vcare Pharmatech Co., Ltd (CN) 2012-12-12 EP disclosed
CN-102775421-A Hydrochloride of 2-hydroxy tetrahydrothienopyridine derivatives, and preparation method and medical application thereof JIANGSU VCARE PHARMATECH CO LTD 2012-11-14 CN disclosed
CN-102775421-A Hydrochloride of 2-hydroxy tetrahydrothienopyridine derivatives, and preparation method and medical application thereof JIANGSU VCARE PHARMATECH CO LTD 2012-11-14 CN disclosed
CN-102199163-A 2-hydroxy tetrahydrothiophene derivative, preparation method thereof and application thereof in pharmacy UNIV CHINA PHARMA 2011-09-28 CN disclosed
WO-2011095049-A1 OPTICALLY ACTIVE 2-HYDROXY TETRAHYDROTHIENOPYRIDINE DERIVATIVES, PREPARATION METHOD AND USE IN MANUFACTURE OF MEDICAMENT THEREOF 江苏威凯尔医药科技有限公司 (CN) 2011-08-11 WO disclosed
CN-102120744-A Optically active 2-hydroxy tetrahydrothienopyridine derivative, preparation method and application thereof in pharmacy JIANGSU VCARE PHARMATECH CO LTD 2011-07-13 CN disclosed
CN-102120744-A Optically active 2-hydroxy tetrahydrothienopyridine derivative, preparation method and application thereof in pharmacy JIANGSU VCARE PHARMATECH CO LTD 2011-07-13 CN disclosed
CN-102120744-A Optically active 2-hydroxy tetrahydrothienopyridine derivative, preparation method and application thereof in pharmacy JIANGSU VCARE PHARMATECH CO LTD 2011-07-13 CN disclosed
CN-102120744-A Optically active 2-hydroxy tetrahydrothienopyridine derivative, preparation method and application thereof in pharmacy JIANGSU VCARE PHARMATECH CO LTD 2011-07-13 CN disclosed