Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Olopatadine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 3/20 | 0.98 |
| ▸ | LMNA | P02545 | 1/20 | 0.98 |
| ▸ | PARP1 | P09874 | 1/20 | 0.77 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.67 |
| ▸ | RECQL | P46063 | 1/20 | 0.67 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.67 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Olopatadine SCHEMBL122589 | 1.00 | HRH1 (0.98) | HRH1LMNAPARP1KDM4EALDH1A1 | |
| Olopatadine SCHEMBL29402772 | 1.00 | HRH1 (0.98) | HRH1LMNAPARP1KDM4EALDH1A1 | |
| Olopatadine SCHEMBL29381853 | 1.00 | HRH1 (0.98) | HRH1LMNAPARP1KDM4EALDH1A1 | |
| Olopatadine SCHEMBL28322959 | 1.00 | HRH1 (0.98) | HRH1LMNAPARP1KDM4EALDH1A1 | |
| Olopatadine SCHEMBL2118055 | 1.00 | HRH1 (0.98) | HRH1LMNAPARP1KDM4EALDH1A1 | |
| Olopatadine SCHEMBL5324205 | 1.00 | HRH1 (0.98) | HRH1LMNAPARP1KDM4EALDH1A1 | |
| Olopatadine SCHEMBL693865 | 0.99 | HRH1 (0.96) | HRH1LMNAPARP1KDM4EALDH1A1 | |
| Olopatadine SCHEMBL693866 | 0.99 | HRH1 (0.96) | HRH1LMNAPARP1KDM4EALDH1A1 | |
| Olopatadine SCHEMBL4669 | 0.99 | HRH1 (1.00) | HRH1LMNAPARP1ALDH1A1KCNH2 | |
| Olopatadine SCHEMBL29517420 | 0.99 | HRH1 (1.00) | HRH1LMNAPARP1ALDH1A1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 4253 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2922553-B1 | TREATMENT OF ALLERGIC RHINITIS USING A COMBINATION OF MOMETASONE AND OLOPATADINE | GLENMARK SPECIALTY SA (CH) | 2026-05-06 | — | — | EP | claimed |
| US-20260076872-A1 | POLYMER VIALS WITH SUBSTANTIALLY FLAT BOTTOMS AND INJECTION STRETCH BLOW MOLDING METHODS FOR MAKING THE SAME | SIO2 MEDICAL PRODUCTS LLC (US) | 2026-03-19 | — | — | US | claimed |
| CN-121570425-A | Olopatadine hydrochloride particles and preparation method thereof | 珠海同源药业有限公司 | 2026-02-27 | — | — | CN | claimed |
| US-20250242092-A1 | SiOx BARRIER FOR PHARMACEUTICAL PACKAGE AND COATING PROCESS | SIO2 MEDICAL PRODUCTS INC (US) | 2025-07-31 | — | — | US | claimed |
| US-20250242115-A1 | DISPENSING DEVICE AND PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF RHINITIS | GLENMARK SPECIALTY S.A. (CH) | 2025-07-31 | — | — | US | claimed |
| EP-4590283-A1 | MUCOADHESIVE DRUG DELIVERY SYSTEMS AND METHODS OF USE | Madd Ophthalmics Ltd. (CA) | 2025-07-30 | — | — | EP | claimed |
| US-12337065-B2 | Compositions for treating viral infections and methods for same | ACCESS TO ADVANCED HEALTH INSTITUTE (US) | 2025-06-24 | — | — | US | claimed |
| CN-120189405-A | Medical application of olopatadine hydrochloride in treating primary liver cancer diseases | 吉林大学 | 2025-06-24 | — | — | CN | claimed |
| WO-2025109499-A1 | NASAL SPRAY COMPOSITION | GLENMARK SPECIALTY S.A. (CH) | 2025-05-30 | — | — | WO | claimed |
| US-20250161328-A1 | NASAL SPRAY COMPOSITION | GLENMARK SPECIALTY S.A. (CH) | 2025-05-22 | — | — | US | claimed |
| WO-2006051287-A1 | COMPOSITION AND METHOD FOR TREATMENT OF ALOPECIA AREATA | ARROW INTERNATIONAL LIMITED (MT) | 2006-05-18 | — | — | WO | claimed |
| US-20050256065-A1 | Method for stabilizing changes in corneal curvature in an eye by administering compositions containing stabilizing ophthalmic agents | PERMASIGHT (US) | 2005-11-17 | — | — | US | claimed |
| EP-1250133-B1 | OPHTHALMIC ANTI-ALLERGY COMPOSITIONS SUITABLE FOR USE WITH CONTACT LENSES | ALCON INC (CH) | 2005-03-30 | — | — | EP | claimed |
| CN-1483478-A | Eye preparation formula adapted for therapentic medicine | 无锡杰西医药科技有限公司 | 2004-03-24 | — | — | CN | claimed |
| JP-2003520813-A | — | — | 2003-07-08 | — | — | JP | claimed |
| EP-1250133-A1 | OPHTHALMIC ANTI-ALLERGY COMPOSITIONS SUITABLE FOR USE WITH CONTACT LENSES | Alcon Universal, Ltd. (CH) | 2002-10-23 | — | — | EP | claimed |
| US-6375973-B2 | OLOPATADINE AND EMEDASTINE AND AN OPHTHALMICALLY ACCEPTABLE POLYMERIC QUATERNARY AMMONIUM COMPOUND AS A PRESERVATIVE | ALCON UNIVERSAL LTD. (CH) | 2002-04-23 | — | — | US | claimed |
| US-20010056093-A1 | Ophthalmic anti-allergy compositions suitable for use with contact lenses | ALCON UNIVERSAL, LTD. | 2001-12-27 | — | — | US | claimed |
| US-20010049369-A1 | Brimonidine compositions and methods for retinal degeneration | UNIVERSITY OF TENNESSEE RESEARCH CORPORATION, THE | 2001-12-06 | — | — | US | claimed |
| WO-2001054687-A1 | OPHTHALMIC ANTI-ALLERGY COMPOSITIONS SUITABLE FOR USE WITH CONTACT LENSES | ALCON UNIVERSAL LTD. (CH) | 2001-08-02 | — | — | WO | claimed |