Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Olopatadine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 3/20 | 0.98 |
| ▸ | LMNA | P02545 | 1/20 | 0.98 |
| ▸ | PARP1 | P09874 | 1/20 | 0.77 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.67 |
| ▸ | RECQL | P46063 | 1/20 | 0.67 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.67 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Olopatadine SCHEMBL122589 | 1.00 | HRH1 (0.98) | HRH1LMNAPARP1KDM4EALDH1A1 | |
| Olopatadine SCHEMBL29402772 | 1.00 | HRH1 (0.98) | HRH1LMNAPARP1KDM4EALDH1A1 | |
| Olopatadine SCHEMBL29381853 | 1.00 | HRH1 (0.98) | HRH1LMNAPARP1KDM4EALDH1A1 | |
| Olopatadine SCHEMBL28322959 | 1.00 | HRH1 (0.98) | HRH1LMNAPARP1KDM4EALDH1A1 | |
| Olopatadine SCHEMBL2118055 | 1.00 | HRH1 (0.98) | HRH1LMNAPARP1KDM4EALDH1A1 | |
| Olopatadine SCHEMBL23213 | 1.00 | HRH1 (0.98) | HRH1LMNAPARP1KDM4EALDH1A1 | |
| Olopatadine SCHEMBL693865 | 0.99 | HRH1 (0.96) | HRH1LMNAPARP1KDM4EALDH1A1 | |
| Olopatadine SCHEMBL693866 | 0.99 | HRH1 (0.96) | HRH1LMNAPARP1KDM4EALDH1A1 | |
| Olopatadine SCHEMBL4669 | 0.99 | HRH1 (1.00) | HRH1LMNAPARP1ALDH1A1KCNH2 | |
| Olopatadine SCHEMBL29517420 | 0.99 | HRH1 (1.00) | HRH1LMNAPARP1ALDH1A1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2922553-A1 | TREATMENT OF ALLERGIC RHINITIS USING A COMBINATION OF MOMETASONE AND OLOPATADINE | Glenmark Pharmaceuticals Limited (IN) | 2015-09-30 | — | — | EP | disclosed |
| WO-2015049665-A1 | TREATMENT OF ALLERGIC RHINITIS USING A COMBINATION OF MOMETASONE AND OLOPATADINE | GLENMARK PHARMACEUTICALS LIMITED (IN) | 2015-04-09 | — | — | WO | disclosed |
| WO-2007105234-A2 | A PROCESS FOR THE PREPARATION OF ISOMERS OF 11-[3-(DIMETHYLAMINO)PROPYLIDENE]-6, 11-DIHYDRODIBENZ [b, e] OXEPIN-2-ACETIC ACID HYDROCHLORIDE AND POLYMORPHS THEREOF | USV LIMITED (IN) | 2007-09-20 | — | — | WO | disclosed |
| US-7247623-B2 | Method of treating dry eye disease with non-drying antihistamines | INSPIRE PHARMACEUTICALS, INC. (US) | 2007-07-24 | — | — | US | disclosed |