Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.59 |
| ▸ | USP2 | O75604 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | CA1 | P00915 | 2/20 | 0.47 |
| ▸ | CA2 | P00918 | 2/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | GAPDH | P04406 | 2/20 | 0.47 |
| ▸ | HRAS | P01112 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | PPM1B | O75688 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.39 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.39 |
| ▸ | TMPRSS2 | O15393 | 1/20 | 0.37 |
| ▸ | PDE5A | O76074 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23240642 | 1.00 | POLB (0.59) | POLBUSP2MEN1KMT2ACA1 | |
| SCHEMBL11390386 | 0.85 | POLB (0.59) | POLBUSP2MEN1KMT2ACA1 | |
| SCHEMBL27055215 | 0.84 | MEN1 (0.41) | POLBUSP2MEN1KMT2ACA1 | |
| SCHEMBL25824041 | 0.84 | MEN1 (0.41) | POLBUSP2MEN1KMT2ACA1 | |
| SCHEMBL24420741 | 0.82 | POLB (0.56) | POLBUSP2MEN1KMT2ACA1 | |
| SCHEMBL11255104 | 0.80 | POLB (0.58) | POLBUSP2MEN1KMT2ACA1 | |
| SCHEMBL23215197 | 0.79 | POLB (0.59) | POLBUSP2MEN1KMT2ACA1 | |
| SCHEMBL23240640 | 0.79 | POLB (0.59) | POLBUSP2MEN1KMT2ACA1 | |
| SCHEMBL11406393 | 0.79 | POLB (0.56) | POLBUSP2MEN1KMT2ACA1 | |
| SCHEMBL11442315 | 0.78 | USP2 (0.62) | POLBUSP2MEN1KMT2ACA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230220384-A1 | OLIGONUCLEOTIDE COMPOSITIONS AND METHODS OF USE THEREOF | WAVE LIFE SCIENCES LTD. (SG) | 2023-07-13 | — | — | US | disclosed |
| EP-4022059-A1 | OLIGONUCLEOTIDE COMPOSITIONS AND METHODS OF USE THEREOF | Wave Life Sciences Ltd. (SG) | 2022-07-06 | — | — | EP | disclosed |
| WO-2021071858-A1 | OLIGONUCLEOTIDE COMPOSITIONS AND METHODS OF USE THEREOF | WAVE LIFE SCIENCES LTD. (SG) | 2021-04-15 | — | — | WO | disclosed |