Tetrahydroberberine

Tetrahydroberberine

SCHEMBL232164

COc1ccc2c(c1OC)CN1CCc3cc4c(cc3C1C2)OCO4

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
F3 P13726 11/20 1.00
DRD1 P21728 9/20 1.00
DRD2 P14416 6/20 1.00
CYP3A4 P08684 3/20 1.00
DRD5 P21918 3/20 1.00
DRD3 P35462 3/20 1.00
CYP1A2 P05177 2/20 1.00
CYP2D6 P10635 2/20 1.00
CYP2C19 P33261 2/20 1.00
DRD4 P21917 2/20 1.00
LMNA P02545 2/20 1.00
ADRA1A P35348 1/20 1.00
MEN1 O00255 1/20 1.00
KMT2A Q03164 1/20 1.00
HTR1A P08908 2/20 0.79
ALOX15 P16050 1/20 0.79
HIF1A Q16665 1/20 0.79
HSD17B10 Q99714 1/20 0.79
KDM4E B2RXH2 1/20 0.79
GAA P10253 1/20 0.79

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Tetrahydroberberine SCHEMBL14184002 1.00 F3 (1.00) F3DRD1DRD2CYP3A4DRD5
Tetrahydroberberine SCHEMBL30484836 1.00 F3 (1.00) F3DRD1DRD2CYP3A4DRD5
Canadine SCHEMBL29365824 1.00 F3 (1.00) F3DRD1DRD2CYP3A4DRD5
Canadine SCHEMBL432394 1.00 F3 (1.00) F3DRD1DRD2CYP3A4DRD5
Tetrahydroberberine SCHEMBL30302597 1.00 F3 (1.00) F3DRD1DRD2CYP3A4DRD5
Tetrahydroberberine SCHEMBL2786492 1.00 F3 (1.00) F3DRD1DRD2CYP3A4DRD5
Tetrahydroberberine SCHEMBL3320124 0.99 F3 (0.98) F3DRD1DRD2CYP3A4DRD5
Tetrahydroberberine SCHEMBL4922203 0.98 F3 (0.96) F3DRD1DRD2CYP3A4DRD5
SCHEMBL2742547 0.91 F3 (0.83) F3DRD1DRD2CYP3A4DRD5
SCHEMBL2742464 0.91 F3 (0.83) F3DRD1DRD2CYP3A4DRD5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1000 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4482322-B1 USE OF AN ANIMAL FEED, DRINKING WATER OR FEED ADDITIVE COMPRISING CANADINE AND/OR A CANADINE DERIVATIVE AS WELL AS BERBERRUBINE PHYTOBIOTICS FUTTERZUSATZSTOFFE GMBH (DE) 2026-05-06 EP claimed
EP-4687856-A2 GLP-1R AGONIST AND DPP-4 INHIBITOR COMPOSITIONS AND METHODS OF USING JDS Therapeutics, LLC (US) 2026-02-11 EP claimed
US-20250228267-A1 ANIMAL FEED OR ANIMAL FEED ADDITIVE COMPRISING CANADINE AND/OR A CANADINE DERIVATIVE PHYTOBIOTICS FUTTERZUSATZSTOFFE GMBH (DE) 2025-07-17 US claimed
CN-120118078-A Tetrahydroberberine derivatives and application thereof 中国药科大学 2025-06-10 CN claimed
CN-119709449-A Construction method of engineering saccharomycetes for efficiently biosynthesizing chelerythrine 上海交通大学 2025-03-28 CN claimed
CN-119570825-A Method for efficiently synthesizing protoberberine compounds and application thereof 中国科学院分子植物科学卓越创新中心 2025-03-07 CN claimed
EP-4514332-A1 ADMINISTRATION OF R-BETA-HYDROXYBUTYRATE AND RELATED COMPOUNDS IN VETERINARY APPLICATIONS Axcess Global Sciences, LLC (US) 2025-03-05 EP claimed
CN-119432631-A Recombinant bacterium and application thereof in production of benzophenanthridine alkaloids 陈云 2025-02-14 CN claimed
CN-119432632-A Recombinant bacterium and application thereof in production of corydaline 陈云 2025-02-14 CN claimed
WO-2025031833-A1 RECOMBINANT STRAIN AND USE THEREOF IN PRODUCTION OF SCOULERINE CHRYSEA LIMITED (IE) 2025-02-13 WO claimed
US-20040156932-A1 Method for decreasing nicotine and other substance use in humans WU, JIE 2004-08-12 US claimed
US-20040091556-A1 Nasal irrigation solutions and methods of using same TIGUNAIT RAJMANI (US) 2004-05-13 US claimed
WO-2004011017-A1 NASAL IRRIGATION SOLUTIONS AND METHODS OF USING SAME HIMALAYAN INTERNATIONAL INSTITUTE OF YOGA SCIENCE AND PHILOSOPHY (US) 2004-02-05 WO claimed
EP-1265485-A1 USE OF PIPERIDINE BENZODERIVATIVES AS FUNGICIDES Leis, Michelangelo (IT) 2002-12-18 EP claimed
WO-2001062089-A1 USE OF PIPERIDINE BENZODERIVATIVES AS FUNGICIDES LEIS MICHELANGELO (IT) 2001-08-30 WO claimed
WO-2000050053-A1 NATURAL PRODUCT COMPOSITION FOR USE IN TREATING CANCER KASS CHAIM DAVID 2000-08-31 WO claimed
US-5876728-A MIXTURE OF HERBAL EXTRACTS OF GOLDENSEAL, MYRTLE AND CENTAUREA Kass, Howard David (US) 1999-03-02 US claimed
CN-1032360-C Preparation method of tetrahydroberberine quaternary ammonium compound CHINA UNIV OF PHARMACY (CN) 1996-07-24 CN claimed
CN-1071666-A Tetrahydroberberine type quaternary ammonium componnd and preparation method thereof CHINA UNIV OF PHARMACY (CN) 1993-05-05 CN claimed
CN-1071766-A Chinese character idol dimly visible keypad code of body (leaf sign indicating number) and input keyboard YE CHUQIANG (CN) 1993-05-05 CN claimed