SCHEMBL23217003

SCHEMBL23217003

CC(NC(=O)c1cnn2ccc(N3CCC[C@@H]3c3cncc(F)c3)nc12)C(F)(F)F

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
JAK2 O60674 18/20 1.00
NTRK1 P04629 18/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2694582 1.00 JAK2 (1.00) JAK2NTRK1
SCHEMBL4103512 1.00 JAK2 (1.00) JAK2NTRK1
SCHEMBL4096265 1.00 JAK2 (1.00) JAK2NTRK1
SCHEMBL2694126 1.00 JAK2 (1.00) JAK2NTRK1
SCHEMBL2694120 1.00 JAK2 (1.00) JAK2NTRK1
SCHEMBL945162 0.93 NTRK1 (1.00) JAK2NTRK1
SCHEMBL945164 0.93 NTRK1 (1.00) JAK2NTRK1
SCHEMBL19987911 0.91 JAK2 (0.83) JAK2NTRK1
SCHEMBL19987910 0.91 JAK2 (0.83) JAK2NTRK1
SCHEMBL2694223 0.90 NTRK1 (1.00) JAK2NTRK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2021072238-A1 FEEDER-BASED AND FEEDER-FREE STEM CELL CULTURE SYSTEMS FOR STRATIFIED EPITHELIAL STEM CELLS, AND USES RELATED THERETO UNIVERSITY OF HOUSTON SYSTEM (US) 2021-04-15 WO disclosed